HitPredict

Interactor 1: MPDZ (O75970)
Multiple PDZ domain protein (Multi-PDZ domain protein 1)
Gene: MPDZ

Interactor 2: 5HT2C (P28335)
5-hydroxytryptamine receptor 2C (5-HT-2C) (5-HT2C) (5-HTR2C) (5-hydroxytryptamine receptor 1C) (5-HT-1C) (5-HT1C) (Serotonin receptor 2C)
Gene: HTR2C

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.672

Property	Details
Experiments	12682077, 11150294, 9537516
Identification Methods	pull down, two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0030425 - dendrite
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2070 Hs			1 458
+	Hs
		280021 MPDZ_HUMAN (1-2070): 0: 1287: 100.00		5HT2A_HUMAN (4-458): 5.97e-84: 267: 50.22
+	Rn
		223210 MPDZ_RAT (1-2070): 0: 1220: 84.50		5HT2C_RAT (1-458): 1.11e-107: 328: 88.04
+	Hs
		280029 MPDZ_HUMAN (1-2070): 0: 1287: 100.00		5HT2B_HUMAN (27-401): 1.83e-70: 233: 44.96
+	Hs
		280028 MPDZ_HUMAN (1-2070): 0: 1287: 100.00		DRD3_HUMAN (22-385): 4.42e-69: 226: 25.79
+	Hs
		658227 DLG1_HUMAN (1619-1915): 1.92e-18: 94.4: 23.06		5HT2C_HUMAN (1-458): 1.97e-103: 317: 100.00
+	Hs
		429068 MAGI3_HUMAN (1157-2070): 7.64e-34: 145: 15.10		ADRB2_HUMAN (22-457): 4.42e-78: 250: 23.70
+	Hs
		441653 MAGI3_HUMAN (1157-2070): 7.64e-34: 145: 15.10		ADRB1_HUMAN (13-409): 5.38e-77: 249: 25.62
+	Mm
		578603 MAGI3_MOUSE (1157-2070): 2.4e-32: 140: 14.89		ADRB2_MOUSE (19-457): 1.77e-79: 254: 23.54
+	Hs
		441654 MAGI2_HUMAN (73-1158): 8.22e-26: 119: 10.36		ADRB1_HUMAN (13-409): 5.38e-77: 249: 25.62
+	Hs
		656997 DLG1_HUMAN (1619-1915): 1.92e-18: 94.4: 23.06		5HT2A_HUMAN (4-458): 5.97e-84: 267: 50.22
+	Hs
		441656 MAGI1_HUMAN (1658-2069): 1.07e-23: 112: 16.64		ADRB1_HUMAN (13-409): 5.38e-77: 249: 25.62
+	Hs
		722923 NHRF3_HUMAN (928-1286): 8.93e-33: 137: 17.21		SSR5_HUMAN (20-400): 9.56e-68: 222: 20.10
+	Hs
		626691 LNX1_HUMAN (782-1270): 1.19e-20: 101: 12.63		ADA1D_HUMAN (24-447): 1.69e-77: 253: 24.47
+	Hs
		626682 DLG1_HUMAN (1619-1915): 1.92e-18: 94.4: 23.06		ADA1D_HUMAN (24-447): 1.69e-77: 253: 24.47
+	Rn
		574798 MAGI3_RAT (1312-1899): 5.54e-24: 113: 14.29		ADRB1_RAT (70-438): 1.1e-70: 233: 26.93
+	Rn
		495779 DLG4_RAT (649-788): 2.68e-17: 90.5: 29.79		ADRB2_RAT (19-438): 1.92e-78: 251: 24.18
+	Mm
		830268 DLG2_MOUSE (1629-2004): 2.56e-24: 113: 21.13		SSR4_MOUSE (23-389): 1.21e-68: 225: 20.57
+	Hs
		783800 LNX1_HUMAN (782-1270): 1.19e-20: 101: 12.63		5HT2B_HUMAN (27-401): 1.83e-70: 233: 44.96
+	Mm
		676813 DLG2_MOUSE (1629-2004): 2.56e-24: 113: 21.13		SSR1_MOUSE (39-387): 1.05e-65: 217: 23.10
+	Hs
		676802 DLG1_HUMAN (1619-1915): 1.92e-18: 94.4: 23.06		SSR1_HUMAN (39-387): 2.15e-64: 214: 23.10