HitPredict

Interactor 1: MPDZ (O75970)
Multiple PDZ domain protein (Multi-PDZ domain protein 1)
Gene: MPDZ

Interactor 2: LIN7C (Q9NUP9)
Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3)
Gene: LIN7C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	L27~L27_2, PDZ~PDZ
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0005923 - bicellular tight junction
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 2070 Hs			1 197
+	Hs
		280072 MPDZ_HUMAN (1-2070): 0: 1287: 100.00		LIN7B_HUMAN (1-196): 4.81e-55: 175: 84.69
+	Hs
		158256 MPDZ_HUMAN (1-2070): 0: 1287: 100.00		LIN7A_HUMAN (6-194): 4.87e-51: 166: 80.42
+	Hs
		1246444 INADL_HUMAN (1922-2068): 4.04e-20: 100: 30.00		LIN7C_HUMAN (1-197): 1.38e-57: 181: 100.00
+	Hs
		1246435 INADL_HUMAN (1922-2068): 4.04e-20: 100: 30.00		LIN7B_HUMAN (1-196): 4.81e-55: 175: 84.69
+	Hs
		158295 INADL_HUMAN (1922-2068): 4.04e-20: 100: 30.00		LIN7A_HUMAN (6-194): 4.87e-51: 166: 80.42
+	Mm
		1143518 MAGI3_MOUSE (1157-2070): 2.4e-32: 140: 14.89		DLG4_MOUSE (59-195): 8.13e-24: 99.8: 26.76
+	Rn
		677805 NHRF3_RAT (1012-1481): 8.36e-32: 134: 14.83		DLG4_RAT (59-195): 2.17e-23: 98.7: 26.76
+	Hs
		1033943 GRIP1_HUMAN (5-671): 8.64e-22: 105: 12.20		SNTB2_HUMAN (61-179): 3e-32: 123: 35.25
+	Mm
		1143467 DLG2_MOUSE (1629-2004): 2.56e-24: 113: 21.13		DLG4_MOUSE (59-195): 8.13e-24: 99.8: 26.76
+	Rn
		1144014 DLG2_RAT (1629-2004): 3.28e-24: 113: 20.67		DLG1_RAT (94-178): 2.77e-21: 92.5: 37.78
+	Mm
		936188 DLG2_MOUSE (1629-2004): 2.56e-24: 113: 21.13		DLG3_MOUSE (60-164): 3.31e-21: 92.5: 32.73
+	Hs
		1232884 LNX2_HUMAN (490-1086): 3.87e-26: 118: 13.72		LNX1_HUMAN (14-179): 1.21e-17: 82.1: 22.02
+	Mm
		250592 LNX1_MOUSE (778-1435): 6.76e-22: 105: 11.45		LNX1_MOUSE (14-179): 4.23e-18: 83.3: 22.62
+	Hs
		1125511 MAGI2_HUMAN (73-1158): 8.22e-26: 119: 10.36		PDZ11_HUMAN (91-175): 4.41e-13: 65.5: 45.35
+	Hs
		1252354 LNX1_HUMAN (782-1270): 1.19e-20: 101: 12.63		LNX1_HUMAN (14-179): 1.21e-17: 82.1: 22.02
+	Hs
		1199788 MAGI2_HUMAN (73-1158): 8.22e-26: 119: 10.36		MAGI1_HUMAN (94-172): 5.41e-10: 60.1: 35.44
+	Hs
		1246425 MAGI1_HUMAN (1658-2069): 1.07e-23: 112: 16.64		INADL_HUMAN (112-194): 6.16e-11: 62.8: 30.12
+	Hs
		1300658 MAGI1_HUMAN (1658-2069): 1.07e-23: 112: 16.64		MAGI1_HUMAN (94-172): 5.41e-10: 60.1: 35.44
+	Hs
		1246409 INADL_HUMAN (1922-2068): 4.04e-20: 100: 30.00		INADL_HUMAN (112-194): 6.16e-11: 62.8: 30.12