HitPredict

Interactor 1: KRT37 (O76014)
Keratin, type I cuticular Ha7 (Hair keratin, type I Ha7) (Keratin-37) (K37)
Gene: KRT37

Interactor 2: TBC21 (Q8IYX1)
TBC1 domain family member 21 (Male germ cell Rab GTPase-activating protein)
Gene: TBC1D21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005856 - cytoskeleton GO:0070062 - extracellular exosome
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 449 Hs			1 336
+	Hs
		280735 KRT34_HUMAN (68-438): 2.7e-155: 447: 62.10		TB22B_HUMAN (1-332): 7.26e-83: 261: 14.72
+	Hs
		1149365 K1C40_HUMAN (1-437): 1.98e-153: 443: 50.23		TB22B_HUMAN (1-332): 7.26e-83: 261: 14.72
+	Hs
		1149247 K1C40_HUMAN (1-437): 1.98e-153: 443: 50.23		TBC16_HUMAN (6-334): 4.03e-77: 253: 19.64
+	Hs
		1149213 K1C40_HUMAN (1-437): 1.98e-153: 443: 50.23		TBC21_HUMAN (1-336): 2.34e-81: 252: 100.00
+	Hs
		580063 K1C15_HUMAN (103-415): 1.79e-94: 294: 52.06		TBC21_HUMAN (1-336): 2.34e-81: 252: 100.00
+	Hs
		281015 KRT38_HUMAN (1-428): 9.91e-82: 261: 94.39		TBC21_HUMAN (1-336): 2.34e-81: 252: 100.00
+	Hs
		1223741 KRT35_HUMAN (1-421): 7.96e-79: 253: 55.34		TBC21_HUMAN (1-336): 2.34e-81: 252: 100.00
+	Hs
		280930 KRT37_HUMAN (1-449): 1.6e-85: 270: 100.00		RBGP1_HUMAN (29-319): 5.53e-67: 229: 14.57
+	Hs
		318833 K2C75_HUMAN (3-429): 9.08e-85: 272: 24.28		TBCD1_HUMAN (32-327): 4.13e-63: 218: 17.49