HitPredict

Interactor 1: WFS1 (O76024)
Wolframin
Gene: WFS1

Interactor 2: TYY1 (P25490)
Transcriptional repressor protein YY1 (Delta transcription factor) (INO80 complex subunit S) (NF-E1) (Yin and yang 1) (YY-1)
Gene: YY1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 890 Hs			1 414
+	Hs
		281874 WFS1_HUMAN (1-890): 0: 1786: 100.00		ZN436_HUMAN (3-291): 1.05e-53: 187: 7.43
+	Hs
		281942 WFS1_HUMAN (1-890): 0: 1786: 100.00		ZN180_HUMAN (9-215): 1.06e-20: 96.3: 7.58
+	Hs
		281652 WFS1_HUMAN (1-890): 0: 1786: 100.00		ZN829_HUMAN (333-414): 7.27e-19: 89.8: 25.00
+	Hs
		281636 WFS1_HUMAN (1-890): 0: 1786: 100.00		ZKSC8_HUMAN (3-184): 7.13e-13: 72: 9.42