HitPredict

Interactor 1: NEBL (O76041)
Nebulette (Actin-binding Z-disk protein)
Gene: NEBL

Interactor 2: DYN2 (P50570)
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Gene: DNM2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~SH3_9
Common GO terms	GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1014 Hs			1 870
+	Hs
		840683 MYO1E_HUMAN (473-1013): 1.11e-48: 190: 11.81		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Mm
		760487 PACN2_MOUSE (634-1013): 5.4e-46: 174: 15.01		DYN2_MOUSE (1-870): 0: 1057: 98.16
+	Hs
		840864 PACN2_HUMAN (634-1013): 2.14e-44: 170: 15.05		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		840812 PACN1_HUMAN (634-1013): 1.44e-42: 163: 15.93		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Mm
		760475 PACN1_MOUSE (634-1013): 4.61e-42: 162: 14.88		DYN2_MOUSE (1-870): 0: 1057: 98.16
+	Hs
		840753 FCSD1_HUMAN (466-1013): 4.62e-39: 157: 11.31		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Mm
		760473 SRC8_MOUSE (523-1012): 2.21e-39: 156: 13.28		DYN2_MOUSE (1-870): 0: 1057: 98.16
+	Mm
		760485 PACN3_MOUSE (634-1013): 2.22e-36: 144: 16.19		DYN2_MOUSE (1-870): 0: 1057: 98.16
+	Hs
		840860 PACN3_HUMAN (634-1013): 9.6e-34: 137: 15.41		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		983372 MYO1E_HUMAN (473-1013): 1.11e-48: 190: 11.81		DYN1_HUMAN (1-846): 0: 1002: 79.04
+	Hs
		983417 PACN2_HUMAN (634-1013): 2.14e-44: 170: 15.05		DYN1_HUMAN (1-846): 0: 1002: 79.04
+	Mm
		760451 PACN1_MOUSE (634-1013): 4.61e-42: 162: 14.88		DYN1_MOUSE (1-844): 0: 1003: 79.23
+	Hs
		983406 PACN1_HUMAN (634-1013): 1.44e-42: 163: 15.93		DYN1_HUMAN (1-846): 0: 1002: 79.04
+	Rn
		599414 PACN1_RAT (634-1013): 5.02e-42: 162: 15.14		DYN1_RAT (1-846): 0: 994: 78.57
+	Mm
		1142989 PACN1_MOUSE (634-1013): 4.61e-42: 162: 14.88		DYN3_MOUSE (1-870): 0: 992: 77.90
+	Rn
		996551 PACN1_RAT (634-1013): 5.02e-42: 162: 15.14		DYN3_RAT (1-870): 0: 991: 77.65
+	Dm
		247616 O61618_DROME (199-1013): 1.92e-58: 220: 10.01		DYN_DROME (6-842): 0: 928: 66.23
+	Dm
		112570 M9ND00_DROME (199-1013): 1.02e-56: 215: 10.18		DYN_DROME (6-842): 0: 928: 66.23
+	Mm
		760455 SH3G3_MOUSE (781-1013): 1.86e-35: 140: 16.40		DYN1_MOUSE (1-844): 0: 1003: 79.23
+	Rn
		192355 SH3G3_RAT (781-1013): 1.34e-35: 140: 16.40		DYN1_RAT (1-846): 0: 994: 78.57