HitPredict

Interactor 1: RNF8 (O76064)
E3 ubiquitin-protein ligase RNF8 (hRNF8) (EC 2.3.2.27) (RING finger protein 8) (RING-type E3 ubiquitin transferase RNF8)
Gene: RNF8

Interactor 2: PCNA (P12004)
Proliferating cell nuclear antigen (PCNA) (Cyclin)
Gene: PCNA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	35831895, 18948756, 22980979
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045739 - positive regulation of DNA repair
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 485 Hs			1 261
+	Hs
		517402 CHFR_HUMAN (37-474): 4.38e-82: 269: 16.59		PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00
+	Hs
		517414 UHRF2_HUMAN (204-472): 7.12e-40: 155: 13.07		PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00
+	Hs
		517317 RFWD3_HUMAN (140-483): 1.84e-37: 148: 16.99		PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00
+	Hs
		517419 UHRF1_HUMAN (206-472): 3.2e-24: 108: 11.96		PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00
+	Hs
		517362 RNF10_HUMAN (176-447): 7.01e-24: 107: 14.13		PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00
+	Hs
		517227 TRI26_HUMAN (391-482): 8.35e-23: 103: 26.32		PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00