HitPredict

Interactor 1: RNF8 (O76064)
E3 ubiquitin-protein ligase RNF8 (hRNF8) (EC 2.3.2.27) (RING finger protein 8) (RING-type E3 ubiquitin transferase RNF8)
Gene: RNF8

Interactor 2: UBE2N (P61088)
Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubc13) (UbcH13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N)
Gene: UBE2N

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.985

The method score is based on:

Property Details
Experiments 25909880, 26285145, 27909234, 29523790, 31048496, 31792955, 21911360, 22589545, 18678647, 22814251, 28244869, 19549727, 20023648, 16215985, 23255131, 24732096
Identification Methods pull down, fluorescent resonance energy transfer, affinity chromatography technology, two hybrid, two hybrid array
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains UQ_con~zf-C3HC4_3
Common GO terms GO:0000151 - ubiquitin ligase complex
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0031625 - ubiquitin protein ligase binding
and 3 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 485
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024