HitPredict

Interactor 1: RNF8 (O76064)
E3 ubiquitin-protein ligase RNF8 (hRNF8) (EC 2.3.2.27) (RING finger protein 8) (RING-type E3 ubiquitin transferase RNF8)
Gene: RNF8

Interactor 2: H2A2C (Q16777)
Histone H2A type 2-C (H2A-clustered histone 20) (Histone H2A-GL101) (Histone H2A/q)
Gene: H2AC20

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	28525740, 22980979
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 485 Hs			1 129
+	Hs
		282470 RNF8_HUMAN (1-485): 0: 523: 100.00		H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49
+	Hs
		282515 RNF8_HUMAN (1-485): 0: 523: 100.00		H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12
+	Mm
		1145463 RNF8_MOUSE (1-484): 3.26e-177: 508: 71.05		H2A2C_MOUSE (1-129): 7.11e-67: 199: 100.00
+	Mm
		1145461 CHFR_MOUSE (37-474): 4.95e-91: 292: 19.68		H2A2C_MOUSE (1-129): 7.11e-67: 199: 100.00
+	Mm
		83335 UHRF1_MOUSE (206-472): 2.94e-26: 114: 12.24		H2A1B_MOUSE (1-127): 8.29e-65: 194: 94.49
+	Hs
		555610 UHRF1_HUMAN (206-472): 3.2e-24: 108: 11.96		H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12
+	Hs
		940968 RNF4_HUMAN (275-450): 3.03e-23: 98.6: 16.13		H2A2C_HUMAN (1-129): 7.11e-67: 199: 100.00
+	Rn
		292376 RNF4_RAT (271-450): 6.15e-23: 98.2: 16.32		H2A3_RAT (1-127): 5.35e-65: 195: 95.28
+	Sc
		392212 IRC20_YEAST (232-473): 1.32e-24: 110: 16.53		H2A1_YEAST (16-129): 1.56e-52: 163: 78.95
+	Sc
		392581 IRC20_YEAST (232-473): 1.32e-24: 110: 16.53		H2A2_YEAST (16-129): 1.63e-52: 163: 78.95