HitPredict

Interactor 1: RNF8 (O76064)
E3 ubiquitin-protein ligase RNF8 (hRNF8) (EC 2.3.2.27) (RING finger protein 8) (RING-type E3 ubiquitin transferase RNF8)
Gene: RNF8

Interactor 2: FILA2 (Q5D862)
Filaggrin-2 (FLG-2) (Intermediate filament-associated and psoriasis-susceptibility protein) (Ifapsoriasin)
Gene: FLG2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35831895
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 485 Hs			1 2391
+	Hs
		282478 RNF8_HUMAN (1-485): 0: 523: 100.00		S10A9_HUMAN (1-109): 6.76e-42: 151: 30.91
+	Hs
		282473 RNF8_HUMAN (1-485): 0: 523: 100.00		S10A8_HUMAN (1-95): 8.99e-36: 133: 29.47
+	Hs
		282525 RNF8_HUMAN (1-485): 0: 523: 100.00		FILA_HUMAN (85-1558): 5.36e-18: 94: 17.52
+	Hs
		282690 RNF8_HUMAN (1-485): 0: 523: 100.00		HORN_HUMAN (1590-2390): 3.13e-13: 78: 17.93
+	Hs
		639056 UHRF1_HUMAN (206-472): 3.2e-24: 108: 11.96		S100P_HUMAN (1-95): 1.9e-43: 155: 41.05
+	Hs
		661388 TRI11_HUMAN (392-472): 5.39e-24: 106: 26.19		S10A2_HUMAN (2-91): 8.89e-40: 145: 32.22
+	Hs
		416400 RNF4_HUMAN (275-450): 3.03e-23: 98.6: 16.13		S10A9_HUMAN (1-109): 6.76e-42: 151: 30.91
+	Hs
		536936 TRI27_HUMAN (392-478): 1.06e-22: 103: 21.11		CTSR1_HUMAN (1604-2010): 6.69e-32: 138: 10.95
+	Hs
		396767 COP1_HUMAN (379-472): 2.35e-22: 102: 24.47		S10A8_HUMAN (1-95): 8.99e-36: 133: 29.47
+	Hs
		416629 LONF2_HUMAN (185-483): 1.04e-29: 125: 14.29		S10A6_HUMAN (4-90): 3.33e-27: 109: 31.03
+	Hs
		416677 TRI11_HUMAN (392-472): 5.39e-24: 106: 26.19		S10A6_HUMAN (4-90): 3.33e-27: 109: 31.03
+	Hs
		1206192 TRIM6_HUMAN (389-468): 4.88e-23: 103: 24.14		HORN_HUMAN (1590-2390): 3.13e-13: 78: 17.93