HitPredict

Interactor 1: PDE9A (O76083)
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35)
Gene: PDE9A

Interactor 2: KRA42 (Q9BYR5)
Keratin-associated protein 4-2 (Keratin-associated protein 4.2) (Ultrahigh sulfur keratin-associated protein 4.2)
Gene: KRTAP4-2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.573

Property	Details
Experiments	25416956
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 593 Hs			1 136
+	Hs
		283294 PDE9A_HUMAN (1-593): 0: 948: 100.00		KR122_HUMAN (1-135): 9.56e-23: 88.5: 33.82
+	Hs
		283316 PDE9A_HUMAN (1-593): 0: 948: 100.00		KRA13_HUMAN (3-135): 4.44e-22: 87.4: 34.57
+	Hs
		283296 PDE9A_HUMAN (1-593): 0: 948: 100.00		KR103_HUMAN (35-136): 1.08e-16: 74.7: 36.36
+	Hs
		283297 PDE9A_HUMAN (1-593): 0: 948: 100.00		KR107_HUMAN (16-136): 3.47e-14: 69.7: 29.63
+	Hs
		283298 PDE9A_HUMAN (1-593): 0: 948: 100.00		KR108_HUMAN (14-136): 9.72e-14: 67.4: 27.48
+	Hs
		283299 PDE9A_HUMAN (1-593): 0: 948: 100.00		KR109_HUMAN (4-116): 3e-13: 66.6: 30.53
+	Hs
		283324 PDE9A_HUMAN (1-593): 0: 948: 100.00		KRA92_HUMAN (33-134): 1.36e-13: 65.8: 43.20
+	Hs
		283295 PDE9A_HUMAN (1-593): 0: 948: 100.00		KR123_HUMAN (51-136): 9.22e-11: 56.6: 33.33
+	Hs
		283302 PDE9A_HUMAN (1-593): 0: 948: 100.00		KRA11_HUMAN (3-124): 1.33e-09: 55: 24.81