HitPredict

Interactor 1: PRS6A (O76371)
26S protease regulatory subunit 6A (Proteasome regulatory particle ATPase-like protein 5)
Gene: rpt-5

Interactor 2: PSA2 (Q27488)
Proteasome subunit alpha type-2 (Proteasome subunit alpha 2)
Gene: pas-2

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	12679813, 14704431, 11559592
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	AAA~Proteasome, AAA~Proteasome_A_N, AAA_lid_3~Proteasome, AAA_lid_3~Proteasome_A_N
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 430 Ce			1 231
+	At
		286460 PRS4A_ARATH (3-424): 2.01e-161: 463: 41.55		PSA5A_ARATH (3-231): 5.62e-94: 276: 32.77
+	At
		1114627 PRS4A_ARATH (3-424): 2.01e-161: 463: 41.55		PSA5B_ARATH (3-231): 2e-93: 275: 32.34
+	At
		286458 PRS4A_ARATH (3-424): 2.01e-161: 463: 41.55		PSA4A_ARATH (1-230): 1.4e-91: 271: 34.17
+	At
		189237 PRS4A_ARATH (3-424): 2.01e-161: 463: 41.55		PSA7B_ARATH (3-228): 3.88e-90: 267: 36.80
+	At
		188699 PRS4A_ARATH (3-424): 2.01e-161: 463: 41.55		PSA2A_ARATH (3-231): 4.91e-89: 264: 53.65
+	At
		1225875 PRS4A_ARATH (3-424): 2.01e-161: 463: 41.55		PSA2B_ARATH (3-231): 2.1e-88: 262: 53.65
+	At
		286451 PRS4A_ARATH (3-424): 2.01e-161: 463: 41.55		PSA6A_ARATH (2-231): 1.68e-87: 260: 36.56
+	At
		672533 PRS4A_ARATH (3-424): 2.01e-161: 463: 41.55		PSA7A_ARATH (3-228): 2.69e-87: 260: 35.50
+	Dm
		771287 PRS4_DROME (6-424): 6.65e-139: 406: 42.08		PSA2_DROME (2-231): 4.04e-109: 314: 60.52
+	Hs
		92615 E9PMD8_HUMAN (19-285): 3.12e-143: 412: 79.55		PSA6_HUMAN (2-231): 5.65e-102: 297: 32.77
+	Hs
		893639 PRS4_HUMAN (5-424): 1.21e-140: 411: 42.22		PSA6_HUMAN (2-231): 5.65e-102: 297: 32.77
+	Dm
		820495 PRS4_DROME (6-424): 6.65e-139: 406: 42.08		PSA5_DROME (3-231): 4.28e-92: 272: 31.67
+	Hs
		92602 E9PMD8_HUMAN (19-285): 3.12e-143: 412: 79.55		PSA2_HUMAN (3-231): 3.76e-90: 266: 63.79
+	Hs
		92605 E9PMD8_HUMAN (19-285): 3.12e-143: 412: 79.55		PSA5_HUMAN (3-231): 3.82e-90: 266: 28.57
+	Hs
		637667 PRS4_HUMAN (5-424): 1.21e-140: 411: 42.22		PSA2_HUMAN (3-231): 3.76e-90: 266: 63.79
+	Hs
		656193 PRS4_HUMAN (5-424): 1.21e-140: 411: 42.22		PSA5_HUMAN (3-231): 3.82e-90: 266: 28.57
+	Hs
		156269 PRS4_HUMAN (5-424): 1.21e-140: 411: 42.22		PSA7_HUMAN (5-229): 1.95e-88: 263: 32.90
+	Hs
		92604 E9PMD8_HUMAN (19-285): 3.12e-143: 412: 79.55		PSA4_HUMAN (1-228): 3.53e-88: 262: 34.03
+	Hs
		638104 PRS4_HUMAN (5-424): 1.21e-140: 411: 42.22		PSA4_HUMAN (1-228): 3.53e-88: 262: 34.03
+	At
		286455 PRS4A_ARATH (3-424): 2.01e-161: 463: 41.55		PSA6B_ARATH (2-228): 1.86e-39: 137: 36.17