HitPredict

Interactor 1: EPN1 (O88339)
Epsin-1 (EPS-15-interacting protein 1)
Gene: EPN1

Interactor 2: CLH1 (P11442)
Clathrin heavy chain 1
Gene: Cltc

Species: Rattus norvegicus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	11382783, 12234931, 10692452
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005905 - clathrin-coated pit GO:0043195 - terminal bouton GO:0048268 - clathrin coat assembly
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 575 Rn			1 1675
+	Hs
		961040 EPN1_HUMAN (1-575): 2e-90: 291: 94.44		CLH1_HUMAN (1-1675): 0: 3132: 99.76
+	Hs
		960794 EPN4_HUMAN (3-560): 2.7e-80: 266: 25.43		CLH1_HUMAN (1-1675): 0: 3132: 99.76
+	Hs
		307526 EPN2_HUMAN (1-565): 9.06e-52: 189: 35.27		CLH1_HUMAN (1-1675): 0: 3132: 99.76
+	Hs
		867091 SC24C_HUMAN (360-571): 5.91e-10: 64.3: 14.47		CLH1_HUMAN (1-1675): 0: 3132: 99.76
+	Hs
		863938 EPN4_HUMAN (3-560): 2.7e-80: 266: 25.43		CLH2_HUMAN (1-1634): 0: 2868: 84.76
+	Dm
		669592 Q7KU90_DROME (1-563): 8.23e-50: 186: 31.30		CLH_DROME (1-1663): 0: 2911: 80.05
+	At
		1012797 EPN1_ARATH (2-448): 1.01e-65: 226: 21.35		CLAH1_ARATH (6-1636): 0: 2638: 56.32
+	At
		1012719 EPN2_ARATH (2-573): 5.3e-39: 154: 19.69		CLAH2_ARATH (6-1636): 0: 2650: 56.56
+	Sc
		604440 ENT3_YEAST (4-428): 3.5e-73: 241: 24.59		CLH_YEAST (5-1648): 0: 2442: 49.79
+	Sc
		604493 ENT1_YEAST (3-225): 5.58e-63: 215: 37.22		CLH_YEAST (5-1648): 0: 2442: 49.79
+	Sc
		604473 ENT2_YEAST (3-528): 7.66e-59: 208: 17.67		CLH_YEAST (5-1648): 0: 2442: 49.79
+	Sc
		604463 ENT5_YEAST (3-345): 1.34e-39: 151: 17.96		CLH_YEAST (5-1648): 0: 2442: 49.79