HitPredict

Interactor 1: EPN1 (O88339)
Epsin-1 (EPS-15-interacting protein 1)
Gene: EPN1

Interactor 2: AP2B1 (P62944)
AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
Gene: AP2B1

Species: Rattus norvegicus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	16903783, 12234931, 10692452
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0030276 - clathrin binding GO:0048268 - clathrin coat assembly GO:0098794 - postsynapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 575 Rn			1 937
+	Hs
		926065 EPN1_HUMAN (1-575): 2e-90: 291: 94.44		AP2B1_HUMAN (1-937): 0: 926: 100.00
+	Hs
		925867 EPN4_HUMAN (3-560): 2.7e-80: 266: 25.43		AP2B1_HUMAN (1-937): 0: 926: 100.00
+	Hs
		1014105 EPN1_HUMAN (1-575): 2e-90: 291: 94.44		AP1B1_HUMAN (1-937): 0: 888: 82.72
+	Hs
		1014011 EPN4_HUMAN (3-560): 2.7e-80: 266: 25.43		AP1B1_HUMAN (1-937): 0: 888: 82.72
+	Rn
		923862 EPN2_RAT (1-572): 2.92e-65: 225: 43.17		AP2B1_RAT (1-937): 0: 926: 100.00
+	Hs
		307524 EPN2_HUMAN (1-565): 9.06e-52: 189: 35.27		AP2B1_HUMAN (1-937): 0: 926: 100.00
+	Dm
		1096902 Q8IN05_DROME (3-430): 5.86e-87: 296: 27.01		Q24253_DROME (1-937): 0: 804: 71.75
+	Dm
		1096905 Q9VD13_DROME (3-566): 5.49e-67: 231: 22.50		Q24253_DROME (1-937): 0: 804: 71.75
+	Rn
		88757 EPN1_RAT (1-575): 2.97e-96: 306: 100.00		D3ZUY8_RAT (11-932): 0: 625: 17.14
+	Hs
		321680 EPN1_HUMAN (1-575): 2e-90: 291: 94.44		AP2A1_HUMAN (11-932): 0: 634: 16.97
+	Rn
		291387 EPN1_RAT (1-575): 2.97e-96: 306: 100.00		AP2A2_RAT (11-932): 0: 595: 16.50
+	Hs
		321545 EPN4_HUMAN (3-560): 2.7e-80: 266: 25.43		AP2A1_HUMAN (11-932): 0: 634: 16.97
+	Rn
		291395 EPN1_RAT (1-575): 2.97e-96: 306: 100.00		Q66HM2_RAT (11-932): 0: 590: 16.38
+	Hs
		302230 EPN1_HUMAN (1-575): 2e-90: 291: 94.44		AP2A2_HUMAN (11-933): 0: 600: 16.99
+	Hs
		302148 EPN4_HUMAN (3-560): 2.7e-80: 266: 25.43		AP2A2_HUMAN (11-933): 0: 600: 16.99
+	Hs
		212629 EPN4_HUMAN (3-560): 2.7e-80: 266: 25.43		AP1G1_HUMAN (11-808): 1.03e-173: 527: 17.57
+	At
		1228257 EPN1_ARATH (2-448): 1.01e-65: 226: 21.35		AP2A1_ARATH (13-934): 0: 556: 16.10
+	Dm
		954828 Q7KU90_DROME (1-563): 8.23e-50: 186: 31.30		AP2A_DROME (11-931): 0: 573: 16.72
+	At
		1195469 EPN1_ARATH (2-448): 1.01e-65: 226: 21.35		AP1G1_ARATH (14-809): 2.91e-173: 527: 16.34
+	At
		1147101 EPN2_ARATH (2-573): 5.3e-39: 154: 19.69		AP2A1_ARATH (13-934): 0: 556: 16.10