HitPredict

Interactor 1: IKKB (O88351)
Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1)
Gene: Ikbkb

Interactor 2: NEMO (O88522)
NF-kappa-B essential modulator (NEMO) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: Ikbkg

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.984

The method score is based on:

Property Details
Experiments 32978373, 21606193, 16378096, 10748240, 12808104, 23871670, 24240172, 23825957, 20404153, 18216269, 16306937, 21552281, 21703539, 21949249, 16613850, 20211142, 18266467, 24270572
Identification Methods affinity chromatography technology, enzymatic study, anti bait coimmunoprecipitation, molecular sieving, anti tag coimmunoprecipitation, pull down
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains IKKbetaNEMObind~NEMO
Common GO terms GO:0001782 - B cell homeostasis
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0007249 - canonical NF-kappaB signal transduction
GO:0008385 - IkappaB kinase complex
and 5 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 757
Mm

1 412
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+ Bt
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+ Bt
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+ Mm
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+ Hs

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Last updated: 15 Jul 2024