HitPredict

Interactor 1: IKKB (O88351)
Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1)
Gene: Ikbkb

Interactor 2: IKBA (Q9Z1E3)
NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha)
Gene: Nfkbia

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.78 1.00 0.885

The method score is based on:

Property Details
Experiments 21765415, 21862579, 22037600, 14636585
Identification Methods enzymatic study, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Ank_2~Pkinase, Ank_5~Pkinase
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0007249 - canonical NF-kappaB signal transduction
GO:0033209 - tumor necrosis factor-mediated signaling pathway
GO:0044877 - protein-containing complex binding
and 1 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 757
Mm

1 314
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024