HitPredict

Interactor 1: MAGI2 (O88382)
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Atrophin-1-interacting protein 1) (AIP-1) (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Synaptic-scaffolding molecule) (S-SCAM)
Gene: MAGI2

Interactor 2: NMDE3 (Q00961)
Glutamate receptor ionotropic, NMDA 2C (GluN2C) (Glutamate [NMDA] receptor subunit epsilon-3) (N-methyl D-aspartate receptor subtype 2C) (NMDAR2C) (NR2C)
Gene: Grin2c

Species: Rattus norvegicus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.53	0.60	0.565

Property	Details
Experiments	10080919, 9694864
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1277 Rn			1 1237
+	Rn
		291500 MAGI2_RAT (1-1277): 0: 758: 100.00		NMDE1_RAT (4-922): 0: 785: 54.90
+	Rn
		291493 MAGI2_RAT (1-1277): 0: 758: 100.00		NMDZ1_RAT (9-944): 0: 681: 22.85
+	Rn
		291503 MAGI2_RAT (1-1277): 0: 758: 100.00		GRID1_RAT (8-983): 0: 635: 18.96
+	Hs
		1028139 SCRIB_HUMAN (121-1071): 6.35e-43: 174: 12.74		NMDE2_HUMAN (9-925): 0: 829: 54.52
+	Hs
		1028142 MAGI3_HUMAN (12-800): 1.58e-28: 127: 10.55		NMDE2_HUMAN (9-925): 0: 829: 54.52
+	Hs
		1028140 DLG2_HUMAN (1128-1271): 1.03e-20: 100: 22.67		NMDE2_HUMAN (9-925): 0: 829: 54.52
+	Rn
		962666 DLG2_RAT (1128-1271): 4.34e-21: 102: 22.67		NMDE2_RAT (9-925): 0: 827: 54.30
+	Mm
		963769 DLG2_MOUSE (1128-1271): 4.9e-21: 102: 22.67		NMDE2_MOUSE (9-925): 0: 822: 54.19
+	Mm
		723540 GRIP1_MOUSE (742-1268): 1.73e-32: 139: 14.43		NMDE1_MOUSE (4-922): 0: 782: 55.01
+	Rn
		962657 DLG2_RAT (1128-1271): 4.34e-21: 102: 22.67		NMDE1_RAT (4-922): 0: 785: 54.90
+	Hs
		1018896 DLG2_HUMAN (1128-1271): 1.03e-20: 100: 22.67		NMDE1_HUMAN (4-922): 0: 771: 54.90
+	Mm
		620904 DLG2_MOUSE (1128-1271): 4.9e-21: 102: 22.67		GRIA1_MOUSE (7-917): 0: 698: 21.22
+	Rn
		585138 DLG4_RAT (14-322): 3.2e-20: 99: 13.31		GRIA1_RAT (7-917): 0: 700: 21.22
+	Mm
		621022 GRIP1_MOUSE (742-1268): 1.73e-32: 139: 14.43		GRIA2_MOUSE (10-839): 0: 649: 20.41
+	Mm
		723606 DLG2_MOUSE (1128-1271): 4.9e-21: 102: 22.67		NMDZ1_MOUSE (9-944): 0: 680: 22.75
+	Rn
		677765 DLG4_RAT (14-322): 3.2e-20: 99: 13.31		NMDZ1_RAT (9-944): 0: 681: 22.85
+	Rn
		585198 GRIP2_RAT (899-1274): 2.52e-20: 99.8: 13.76		GRIA3_RAT (5-860): 0: 665: 19.91
+	Rn
		1144131 DLG2_RAT (1128-1271): 4.34e-21: 102: 22.67		GRID2_RAT (10-978): 0: 662: 20.27
+	Rn
		585187 GRIP2_RAT (899-1274): 2.52e-20: 99.8: 13.76		GRIA2_RAT (10-854): 0: 649: 20.07
+	Rn
		1143996 DLG2_RAT (1128-1271): 4.34e-21: 102: 22.67		GRID1_RAT (8-983): 0: 635: 18.96