HitPredict

Interactor 1: MAGI2 (O88382)
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Atrophin-1-interacting protein 1) (AIP-1) (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Synaptic-scaffolding molecule) (S-SCAM)
Gene: MAGI2

Interactor 2: NLGN2 (Q62888)
Neuroligin-2
Gene: NLGN2

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	15458844
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0045202 - synapse GO:0098982 - GABA-ergic synapse GO:2000809 - positive regulation of synaptic vesicle clustering
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1277 Rn			1 836
+	Rn
		291504 MAGI2_RAT (1-1277): 0: 758: 100.00		NLGN1_RAT (1-836): 0: 923: 61.00
+	Rn
		1144057 MAGI3_RAT (12-787): 2.04e-27: 123: 10.89		NLGN2_RAT (1-836): 0: 933: 100.00
+	Rn
		1144027 MAGI3_RAT (12-787): 2.04e-27: 123: 10.89		NLGN1_RAT (1-836): 0: 923: 61.00
+	Hs
		1077290 DLG2_HUMAN (1128-1271): 1.03e-20: 100: 22.67		NLGN3_HUMAN (1-836): 0: 938: 60.87
+	Rn
		1144055 DLG2_RAT (1128-1271): 4.34e-21: 102: 22.67		NLGN2_RAT (1-836): 0: 933: 100.00
+	Mm
		1143408 DLG4_MOUSE (370-511): 5.7e-17: 88.5: 26.17		NLGN3_MOUSE (1-836): 0: 946: 62.76
+	Hs
		942360 DLG4_HUMAN (370-511): 5.8e-17: 88.5: 26.17		NLGNX_HUMAN (1-836): 0: 944: 60.85
+	Rn
		677789 DLG4_RAT (14-322): 3.2e-20: 99: 13.31		NLGN2_RAT (1-836): 0: 933: 100.00
+	Mm
		57108 DLG4_MOUSE (370-511): 5.7e-17: 88.5: 26.17		A2AGI2_MOUSE (1-836): 0: 943: 60.98
+	Hs
		1077282 DLG2_HUMAN (1128-1271): 1.03e-20: 100: 22.67		NLGN1_HUMAN (2-836): 0: 931: 59.46
+	Hs
		942388 DLG4_HUMAN (370-511): 5.8e-17: 88.5: 26.17		NLGN3_HUMAN (1-836): 0: 938: 60.87
+	Rn
		1144025 DLG2_RAT (1128-1271): 4.34e-21: 102: 22.67		NLGN1_RAT (1-836): 0: 923: 61.00
+	Mm
		1143338 DLG4_MOUSE (370-511): 5.7e-17: 88.5: 26.17		NLGN2_MOUSE (1-836): 0: 936: 99.88
+	Hs
		1271033 DLG3_HUMAN (14-283): 8.67e-16: 84.8: 11.64		NLGN3_HUMAN (1-836): 0: 938: 60.87
+	Rn
		677788 DLG4_RAT (14-322): 3.2e-20: 99: 13.31		NLGN1_RAT (1-836): 0: 923: 61.00
+	Hs
		942361 DLG4_HUMAN (370-511): 5.8e-17: 88.5: 26.17		NLGN1_HUMAN (2-836): 0: 931: 59.46
+	Hs
		1231765 DLG3_HUMAN (14-283): 8.67e-16: 84.8: 11.64		NLGN1_HUMAN (2-836): 0: 931: 59.46
+	Hs
		1077283 DLG2_HUMAN (1128-1271): 1.03e-20: 100: 22.67		NLGN2_HUMAN (1-836): 0: 904: 98.09
+	Hs
		942363 DLG4_HUMAN (370-511): 5.8e-17: 88.5: 26.17		NLGN2_HUMAN (1-836): 0: 904: 98.09
+	Hs
		1245078 DLG3_HUMAN (14-283): 8.67e-16: 84.8: 11.64		NLGN2_HUMAN (1-836): 0: 904: 98.09