HitPredict

Interactor 1: MAGI2 (O88382)
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Atrophin-1-interacting protein 1) (AIP-1) (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Synaptic-scaffolding molecule) (S-SCAM)
Gene: MAGI2

Interactor 2: GRASP (Q8R4T5)
General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein) (95 kDa postsynaptic density protein discs-large ZO-1 domain-containing protein) (PSD-95 PDZ domain-containing protein) (Tamalin)
Gene: Tamalin

Species: Rattus norvegicus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	1.00	0.819

Property	Details
Experiments	12586822, 17396155
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Guanylate_kin~PDZ, PDZ~PDZ
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0014069 - postsynaptic density GO:0048471 - perinuclear region of cytoplasm GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1277 Rn			1 394
+	Rn
		677802 DLG4_RAT (14-322): 3.2e-20: 99: 13.31		GRASP_RAT (1-394): 9.35e-106: 318: 100.00
+	Hs
		230867 PTN13_HUMAN (648-1273): 1.06e-35: 150: 14.93		MAST3_HUMAN (24-326): 7.44e-40: 153: 19.88
+	Mm
		1194592 GRIP1_MOUSE (742-1268): 1.73e-32: 139: 14.43		SHAN2_MOUSE (17-338): 5.34e-35: 139: 17.09
+	Hs
		1298929 LRRC7_HUMAN (499-1222): 1.67e-29: 130: 15.25		SHAN1_HUMAN (51-334): 1.21e-36: 144: 18.79
+	Hs
		942399 DLG4_HUMAN (370-511): 5.8e-17: 88.5: 26.17		SHAN2_HUMAN (17-338): 5.9e-41: 156: 16.72
+	Rn
		1144361 DLG2_RAT (1128-1271): 4.34e-21: 102: 22.67		SHAN1_RAT (51-334): 3.89e-34: 136: 17.50
+	Rn
		677807 DLG4_RAT (14-322): 3.2e-20: 99: 13.31		SHAN1_RAT (51-334): 3.89e-34: 136: 17.50
+	Hs
		942404 DLG4_HUMAN (370-511): 5.8e-17: 88.5: 26.17		SHAN1_HUMAN (51-334): 1.21e-36: 144: 18.79
+	Rn
		957065 GRIP1_RAT (887-1248): 7.87e-18: 91.7: 14.91		SHAN1_RAT (51-334): 3.89e-34: 136: 17.50
+	Mm
		1143381 DLG4_MOUSE (370-511): 5.7e-17: 88.5: 26.17		SHAN2_MOUSE (17-338): 5.34e-35: 139: 17.09
+	Mm
		88371 DLG4_MOUSE (370-511): 5.7e-17: 88.5: 26.17		SHAN1_MOUSE (51-334): 3.75e-34: 136: 18.69
+	Mm
		1112558 DLG4_MOUSE (370-511): 5.7e-17: 88.5: 26.17		SNX27_MOUSE (98-230): 1.21e-33: 133: 24.82
+	Mm
		1143518 DLG4_MOUSE (370-511): 5.7e-17: 88.5: 26.17		MAGI3_MOUSE (69-283): 2.33e-28: 119: 19.46
+	Rn
		677805 DLG4_RAT (14-322): 3.2e-20: 99: 13.31		NHRF3_RAT (46-360): 1.34e-20: 95.6: 15.27
+	Hs
		1246425 INADL_HUMAN (836-1259): 9.4e-30: 130: 15.32		MAGI1_HUMAN (10-226): 1.2e-09: 62.3: 13.36
+	Mm
		1116062 DLG2_MOUSE (1128-1271): 4.9e-21: 102: 22.67		SHAN3_MOUSE (99-334): 6.42e-15: 78.7: 20.24
+	Mm
		1115938 DLG4_MOUSE (370-511): 5.7e-17: 88.5: 26.17		SHAN3_MOUSE (99-334): 6.42e-15: 78.7: 20.24
+	Rn
		1376702 GRIP2_RAT (899-1274): 2.52e-20: 99.8: 13.76		GRIP2_RAT (82-337): 7.45e-09: 59.7: 11.63
+	Mm
		936801 DLG4_MOUSE (370-511): 5.7e-17: 88.5: 26.17		NHRF1_MOUSE (95-253): 2.44e-10: 63.3: 23.17
+	Rn
		957062 GRIP1_RAT (887-1248): 7.87e-18: 91.7: 14.91		GRIP2_RAT (82-337): 7.45e-09: 59.7: 11.63