Interactor 1: DNM3A (O88508)
DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase MmuIIIA) (DNA MTase MmuIIIA) (M.MmuIIIA)
Gene: Dnmt3a

Interactor 2: DNM3A (O88508)
DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase MmuIIIA) (DNA MTase MmuIIIA) (M.MmuIIIA)
Gene: Dnmt3a

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.60 1.00 0.778

The method score is based on:

Property Details
Experiments 17713477, 21481189
Identification Methods molecular sieving, methyltransferase assay
Interaction Type direct interaction, methylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains ADD_DNMT3~ADD_DNMT3, DNA_methylase~DNA_methylase, PWWP~PWWP
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000775 - chromosome, centromeric region
GO:0000791 - euchromatin
GO:0000792 - heterochromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
and 38 others

more...

Homologous interactions 8

Homologous interactions

Color coding for hit scores

1 908
Mm

1 908
+ Hs
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Mm
+ Mm

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Last updated: 15 Jul 2024