HitPredict

Interactor 1: NEMO (O88522)
NF-kappa-B essential modulator (NEMO) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: Ikbkg

Interactor 2: IKBB (Q60778)
NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta)
Gene: Nfkbib

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	16301747, 16260493
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ank_2~CC2-LZ
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Mm			1 359
+	Mm
		291826 NEMO_MOUSE (1-412): 2.4e-74: 239: 100.00		IKBA_MOUSE (7-338): 1.38e-81: 253: 31.29
+	Hs
		1076400 NEMO_HUMAN (1-412): 1.2e-68: 224: 86.40		IKBB_HUMAN (1-358): 1.9e-76: 241: 83.24
+	Hs
		961453 NEMO_HUMAN (1-412): 1.2e-68: 224: 86.40		NFKB2_HUMAN (35-330): 7.86e-69: 233: 30.13
+	Hs
		121608 NEMO_HUMAN (1-412): 1.2e-68: 224: 86.40		IKBE_HUMAN (25-331): 4.6e-71: 231: 32.48
+	Hs
		862142 NEMO_HUMAN (1-412): 1.2e-68: 224: 86.40		DAPK1_HUMAN (7-154): 1.36e-30: 125: 24.84
+	Hs
		883695 NEMO_HUMAN (1-412): 1.2e-68: 224: 86.40		RIPK4_HUMAN (1-97): 1.21e-16: 83.4: 22.55
+	Hs
		1330909 NEMO_HUMAN (1-412): 1.2e-68: 224: 86.40		Q9H4D1_HUMAN (1-97): 1.87e-16: 82.6: 22.55
+	Bt
		1259265 NEMO_BOVIN (1-412): 1.02e-70: 230: 82.82		Q8WNW7_BOVIN (46-181): 5.81e-12: 67.5: 22.63
+	Hs
		587763 NEMO_HUMAN (1-412): 1.2e-68: 224: 86.40		NFKB1_HUMAN (202-296): 8.37e-13: 71.8: 30.00
+	Hs
		639834 NEMO_HUMAN (1-412): 1.2e-68: 224: 86.40		IKBA_HUMAN (17-171): 2.72e-12: 68.7: 23.57
+	Hs
		1216417 MY18B_HUMAN (35-384): 4.83e-35: 139: 14.54		TNKS2_HUMAN (211-352): 6.76e-33: 131: 23.08
+	Hs
		862127 MYO5B_HUMAN (61-387): 7.82e-29: 121: 15.54		DAPK1_HUMAN (7-154): 1.36e-30: 125: 24.84
+	Hs
		1021434 DLG5_HUMAN (52-337): 4.37e-10: 63.8: 14.09		ANK3_HUMAN (147-356): 6.22e-43: 161: 19.52
+	Hs
		1219814 OPTN_HUMAN (67-411): 1.74e-36: 142: 26.40		ANKH1_HUMAN (265-356): 1.43e-14: 77.2: 13.98
+	Hs
		1078859 ITSN1_HUMAN (12-368): 5e-36: 142: 15.31		MIB1_HUMAN (214-329): 1.52e-12: 71: 17.24
+	Hs
		1078921 ITSN1_HUMAN (12-368): 5e-36: 142: 15.31		RAI14_HUMAN (94-266): 1.42e-12: 70.9: 31.64
+	Hs
		257713 ITSN2_HUMAN (2-383): 8.92e-25: 109: 13.69		ANR17_HUMAN (266-358): 9.57e-18: 86.9: 13.83
+	Hs
		1268104 MY18A_HUMAN (33-384): 1.23e-29: 123: 17.26		RAI14_HUMAN (94-266): 1.42e-12: 70.9: 31.64
+	Hs
		1329250 TARA_HUMAN (30-279): 7.09e-27: 115: 19.47		RAI14_HUMAN (94-266): 1.42e-12: 70.9: 31.64
+	Hs
		1255141 DLG5_HUMAN (52-337): 4.37e-10: 63.8: 14.09		ANFY1_HUMAN (27-163): 5.26e-12: 69.1: 22.60