HitPredict

Interactor 1: NEMO (O88522)
NF-kappa-B essential modulator (NEMO) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: Ikbkg

Interactor 2: RNF31 (Q924T7)
E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (Putative Ariadne-like ubiquitin ligase) (PAUL) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31)
Gene: RNF31

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 0.60 0.705

The method score is based on:

Property Details
Experiments 21455181, 19136968, 24469399, 21811235
Identification Methods enzymatic study, affinity chromatography technology, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0033209 - tumor necrosis factor-mediated signaling pathway
GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
GO:0051092 - positive regulation of NF-kappaB transcription factor activity
GO:0070530 - K63-linked polyubiquitin modification-dependent protein binding
GO:1990450 - linear polyubiquitin binding
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 412
Mm

1 1066
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024