HitPredict

Interactor 1: NEMO (O88522)
NF-kappa-B essential modulator (NEMO) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: Ikbkg

Interactor 2: IKKE (Q9R0T8)
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
Gene: Ikbke

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	21949249
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Mm			1 717
+	Mm
		291823 NEMO_MOUSE (1-412): 2.4e-74: 239: 100.00		TBK1_MOUSE (1-717): 3.87e-158: 476: 45.93
+	Hs
		1050315 NEMO_HUMAN (1-412): 1.2e-68: 224: 86.40		IKKE_HUMAN (1-717): 3.38e-161: 483: 82.34
+	Hs
		1355377 NEMO_HUMAN (1-412): 1.2e-68: 224: 86.40		TBK1_HUMAN (1-717): 9.06e-158: 475: 46.07
+	Bt
		1278679 NEMO_BOVIN (1-412): 1.02e-70: 230: 82.82		IKKB_BOVIN (9-702): 3.5e-135: 418: 18.77
+	Hs
		158576 NEMO_HUMAN (1-412): 1.2e-68: 224: 86.40		IKKB_HUMAN (9-702): 9.46e-134: 414: 18.37
+	Mm
		1225238 OPTN_MOUSE (8-411): 2.2e-41: 155: 26.02		TBK1_MOUSE (1-717): 3.87e-158: 476: 45.93
+	Bt
		1278680 NEMO_BOVIN (1-412): 1.02e-70: 230: 82.82		IKKA_BOVIN (9-711): 3.56e-127: 396: 17.47
+	Mm
		291800 NEMO_MOUSE (1-412): 2.4e-74: 239: 100.00		IKKA_MOUSE (9-711): 4.14e-122: 383: 17.35
+	Hs
		1287421 OPTN_HUMAN (67-411): 1.74e-36: 142: 26.40		TBK1_HUMAN (1-717): 9.06e-158: 475: 46.07
+	Mm
		291432 NEMO_MOUSE (1-412): 2.4e-74: 239: 100.00		IKKB_MOUSE (9-702): 8.98e-120: 377: 19.37
+	Hs
		167642 NEMO_HUMAN (1-412): 1.2e-68: 224: 86.40		IKKA_HUMAN (9-711): 3.05e-122: 384: 17.03
+	Hs
		625664 NEMO_HUMAN (1-412): 1.2e-68: 224: 86.40		CDK2_HUMAN (6-312): 1.35e-126: 379: 21.61
+	Hs
		158523 OPTN_HUMAN (67-411): 1.74e-36: 142: 26.40		IKKB_HUMAN (9-702): 9.46e-134: 414: 18.37
+	Hs
		254506 OPTN_HUMAN (67-411): 1.74e-36: 142: 26.40		ROCK2_HUMAN (7-706): 1.12e-124: 405: 15.67
+	Mm
		291472 OPTN_MOUSE (8-411): 2.2e-41: 155: 26.02		IKKB_MOUSE (9-702): 8.98e-120: 377: 19.37
+	Hs
		625548 OPTN_HUMAN (67-411): 1.74e-36: 142: 26.40		CDK2_HUMAN (6-312): 1.35e-126: 379: 21.61
+	Hs
		625530 MY18A_HUMAN (33-384): 1.23e-29: 123: 17.26		CDK2_HUMAN (6-312): 1.35e-126: 379: 21.61
+	Hs
		862142 NEMO_HUMAN (1-412): 1.2e-68: 224: 86.40		DAPK1_HUMAN (2-222): 1.36e-20: 99.4: 31.42
+	Hs
		262300 OPTN_HUMAN (67-411): 1.74e-36: 142: 26.40		ULK1_HUMAN (13-221): 1.14e-22: 105: 32.41
+	Hs
		200129 MY18A_HUMAN (33-384): 1.23e-29: 123: 17.26		DAPK3_HUMAN (15-222): 5.36e-21: 98.6: 32.86