HitPredict

Interactor 1: CSN4 (O88544)
COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4)
Gene: Cops4

Interactor 2: CSN2 (P61202)
COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15)
Gene: Cops2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24973710
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CSN4_RPN5_eIF3a~PCI, PCI~PCI
Common GO terms	GO:0000338 - protein deneddylation GO:0008180 - COP9 signalosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 406 Mm			1 443
+	Hs
		897302 CSN4_HUMAN (1-406): 6.58e-168: 478: 99.51		CSN2_HUMAN (1-443): 3.15e-127: 377: 100.00
+	Dm
		1277030 CSN4_DROME (3-395): 1.79e-154: 443: 72.52		CSN2_DROME (16-443): 5.59e-115: 345: 83.92
+	Mm
		102342 CSN4_MOUSE (1-406): 3.81e-168: 478: 100.00		G3UXW9_MOUSE (17-443): 1.81e-80: 259: 15.39
+	Hs
		1024211 CSN4_HUMAN (1-406): 6.58e-168: 478: 99.51		CSN1_HUMAN (17-443): 7.03e-80: 257: 15.02
+	Dm
		1180709 CSN4_DROME (3-395): 1.79e-154: 443: 72.52		PSD11_DROME (36-442): 4.15e-87: 273: 20.34
+	Hs
		1311889 CSN4_HUMAN (1-406): 6.58e-168: 478: 99.51		CSN4_HUMAN (54-440): 8.14e-74: 238: 16.25
+	At
		1226050 CSN4_ARATH (17-391): 7.5e-124: 365: 49.35		CSN2_ARATH (12-442): 5.56e-115: 345: 61.20
+	Ce
		136318 CSN4_CAEEL (7-395): 5.25e-117: 348: 36.00		CSN2_CAEEL (17-417): 3.31e-102: 315: 65.93
+	An
		1124316 CSN4_EMENI (13-392): 1.6e-110: 332: 39.19		CSN2_EMENI (1-440): 6.53e-108: 330: 50.67
+	Hs
		121629 PSD12_HUMAN (7-392): 5.78e-122: 362: 19.52		PSD11_HUMAN (35-442): 5.44e-89: 278: 22.43
+	Hs
		122017 PSD12_HUMAN (7-392): 5.78e-122: 362: 19.52		PSMD6_HUMAN (55-440): 4.29e-87: 272: 13.01
+	Hs
		121886 PSD12_HUMAN (7-392): 5.78e-122: 362: 19.52		PSD12_HUMAN (39-440): 8.69e-83: 263: 12.80
+	Dm
		1180715 Q9V3Z4_DROME (7-392): 7.25e-102: 313: 17.37		PSD11_DROME (36-442): 4.15e-87: 273: 20.34
+	Dm
		1358525 Q9V3Z4_DROME (7-392): 7.25e-102: 313: 17.37		PSMD6_DROME (58-439): 1.55e-80: 255: 12.89
+	Sc
		1015374 RPN5_YEAST (8-392): 2.29e-105: 320: 18.45		RPN6_YEAST (67-443): 8.69e-76: 245: 21.43
+	At
		1226046 CSN4_ARATH (17-391): 7.5e-124: 365: 49.35		CSN4_ARATH (73-439): 8.3e-58: 196: 15.21
+	Ce
		1341524 CSN4_CAEEL (7-395): 5.25e-117: 348: 36.00		CSN4_CAEEL (121-443): 2.79e-57: 195: 15.02
+	At
		799471 CSN4_ARATH (17-391): 7.5e-124: 365: 49.35		CSN1_ARATH (231-442): 2.95e-44: 162: 21.15
+	Ce
		1325699 CSN4_CAEEL (7-395): 5.25e-117: 348: 36.00		CSN1_CAEEL (164-427): 4e-24: 107: 14.82
+	An
		1319499 CSN4_EMENI (13-392): 1.6e-110: 332: 39.19		CSN4_EMENI (92-438): 2.32e-23: 103: 14.71