HitPredict

Interactor 1: CLD2 (O88552)
Claudin-2
Gene: Cldn2

Interactor 2: ZO1 (P39447)
Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1)
Gene: Tjp1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	10601346
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005923 - bicellular tight junction GO:0016020 - membrane GO:0070160 - tight junction GO:0098609 - cell-cell adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 230 Mm			1 1745
+	Hs
		881971 CLD8_HUMAN (1-230): 1.55e-88: 262: 33.77		ZO1_HUMAN (1-1745): 0: 989: 90.79
+	Mm
		192030 CLD4_MOUSE (1-209): 8.88e-86: 254: 39.71		ZO1_MOUSE (1-1745): 0: 993: 100.00
+	Mm
		761869 CLD8_MOUSE (1-230): 3.47e-85: 253: 32.47		ZO1_MOUSE (1-1745): 0: 993: 100.00
+	Hs
		315115 CLD7_HUMAN (1-209): 1.58e-86: 256: 35.24		ZO1_HUMAN (1-1745): 0: 989: 90.79
+	Mm
		291871 CLD1_MOUSE (1-208): 2.32e-83: 248: 37.32		ZO1_MOUSE (1-1745): 0: 993: 100.00
+	Mm
		761870 CLD7_MOUSE (1-209): 9.21e-82: 244: 36.19		ZO1_MOUSE (1-1745): 0: 993: 100.00
+	Hs
		884672 CLD2_HUMAN (1-230): 4.65e-82: 246: 91.30		ZO1_HUMAN (1-1745): 0: 989: 90.79
+	Mm
		222686 CLD5_MOUSE (1-214): 4.18e-79: 238: 31.48		ZO1_MOUSE (1-1745): 0: 993: 100.00
+	Hs
		131310 CLD5_HUMAN (1-214): 2.94e-80: 241: 32.87		ZO1_HUMAN (1-1745): 0: 989: 90.79
+	Hs
		881967 CLD6_HUMAN (1-209): 9.9e-80: 239: 36.97		ZO1_HUMAN (1-1745): 0: 989: 90.79
+	Hs
		146030 CLD4_HUMAN (1-192): 4.41e-79: 238: 40.63		ZO1_HUMAN (1-1745): 0: 989: 90.79
+	Hs
		325492 CLD1_HUMAN (1-209): 3.96e-78: 235: 35.71		ZO1_HUMAN (1-1745): 0: 989: 90.79
+	Mm
		291873 CLD1_MOUSE (1-208): 2.32e-83: 248: 37.32		ZO3_MOUSE (13-925): 3.01e-132: 438: 38.42
+	Hs
		303739 CLD1_HUMAN (1-209): 3.96e-78: 235: 35.71		ZO3_HUMAN (13-927): 7.42e-137: 451: 39.28
+	Mm
		192031 CLD4_MOUSE (1-209): 8.88e-86: 254: 39.71		MPDZ_MOUSE (6-329): 4.5e-23: 109: 17.13
+	Mm
		291872 CLD1_MOUSE (1-208): 2.32e-83: 248: 37.32		MPDZ_MOUSE (6-329): 4.5e-23: 109: 17.13
+	Hs
		884690 CLD2_HUMAN (1-230): 4.65e-82: 246: 91.30		ZO2_HUMAN (170-518): 1.13e-18: 95.4: 14.47
+	Hs
		146034 CLD4_HUMAN (1-192): 4.41e-79: 238: 40.63		DLG1_HUMAN (264-512): 3.5e-15: 83.4: 15.95
+	Hs
		325496 CLD1_HUMAN (1-209): 3.96e-78: 235: 35.71		INADL_HUMAN (51-506): 3.52e-15: 84.1: 14.56
+	Mm
		291874 CLD1_MOUSE (1-208): 2.32e-83: 248: 37.32		ZO2_MOUSE (413-562): 4.65e-09: 63.8: 21.52