HitPredict

Interactor 1: BECN1 (O88597)
Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa]
Gene: BECN1

Interactor 2: BCL2 (P10417)
Apoptosis regulator Bcl-2
Gene: BCL2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.958

The method score is based on:

Property	Details
Experiments	18772134, 28347844, 29157081, 18281291, 22258505, 20819940, 29849149
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	BH3~Bcl-2
Common GO terms	GO:0005737 - cytoplasm GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol GO:0006915 - apoptotic process GO:0008285 - negative regulation of cell population proliferation and 9 others more... GO:0009410 - response to xenobiotic stimulus GO:0010506 - regulation of autophagy GO:0010507 - negative regulation of autophagy GO:0016020 - membrane GO:0031625 - ubiquitin protein ligase binding GO:0042149 - cellular response to glucose starvation GO:0043066 - negative regulation of apoptotic process GO:0051607 - defense response to virus GO:2000378 - negative regulation of reactive oxygen species metabolic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1	448
Mm

1	236

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024