HitPredict

Interactor 1: HSP74 (O88600)
Heat shock 70 kDa protein 4 (Ischemia responsive 94 kDa protein)
Gene: Hspa4

Interactor 2: TAU (P19332)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: Mapt

Species: Rattus norvegicus

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	32357304
Identification Methods	cross-linking study
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0010629 - negative regulation of gene expression GO:0044877 - protein-containing complex binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 840 Rn			1 752
+	Rn
		94108 HSP74_RAT (1-840): 0: 985: 100.00		F1LST4_RAT (1-751): 5.68e-95: 314: 99.87
+	Mm
		498021 Q3U2G2_MOUSE (1-840): 0: 972: 97.74		TAU_MOUSE (1-752): 1.92e-82: 279: 89.52
+	Mm
		497946 HS74L_MOUSE (1-840): 0: 962: 61.79		TAU_MOUSE (1-752): 1.92e-82: 279: 89.52
+	Hs
		496426 HSP74_HUMAN (1-840): 0: 982: 95.83		TAU_HUMAN (1-752): 2.05e-72: 253: 71.86
+	Hs
		320800 HS74L_HUMAN (1-840): 0: 958: 62.38		TAU_HUMAN (1-752): 2.05e-72: 253: 71.86
+	Mm
		498049 HS105_MOUSE (1-840): 0: 930: 60.93		TAU_MOUSE (1-752): 1.92e-82: 279: 89.52
+	Hs
		497367 HS105_HUMAN (1-840): 0: 929: 61.86		TAU_HUMAN (1-752): 2.05e-72: 253: 71.86
+	Hs
		554275 HSP74_HUMAN (1-840): 0: 982: 95.83		MUC1_HUMAN (5-652): 3.87e-39: 158: 12.50
+	Dm
		1370298 Q9VUC1_DROME (1-840): 0: 833: 41.38		Q9VLS7_DROME (3-541): 3.66e-12: 72.4: 11.77
+	Mm
		498048 HS71A_MOUSE (2-572): 2.47e-83: 281: 32.41		TAU_MOUSE (1-752): 1.92e-82: 279: 89.52
+	Mm
		497918 HS71L_MOUSE (564-692): 5.55e-20: 97: 22.31		TAU_MOUSE (1-752): 1.92e-82: 279: 89.52
+	Mm
		497989 HSP7C_MOUSE (564-692): 6.31e-19: 93.5: 17.69		TAU_MOUSE (1-752): 1.92e-82: 279: 89.52
+	Hs
		483743 HS71A_HUMAN (564-686): 1.27e-19: 95.9: 22.58		TAU_HUMAN (1-752): 2.05e-72: 253: 71.86
+	Hs
		496165 HSP7C_HUMAN (564-692): 2.3e-19: 95.1: 18.46		TAU_HUMAN (1-752): 2.05e-72: 253: 71.86
+	Hs
		496425 HS71L_HUMAN (564-691): 2.01e-19: 95.1: 24.03		TAU_HUMAN (1-752): 2.05e-72: 253: 71.86
+	Hs
		496242 HSP76_HUMAN (563-690): 1.91e-16: 85.8: 20.16		TAU_HUMAN (1-752): 2.05e-72: 253: 71.86
+	Hs
		503487 HSP7C_HUMAN (564-692): 2.3e-19: 95.1: 18.46		MAP4_HUMAN (9-727): 1.28e-34: 144: 19.84
+	Hs
		483759 HS71A_HUMAN (564-686): 1.27e-19: 95.9: 22.58		ANK2_HUMAN (184-667): 3.72e-25: 114: 15.43
+	Hs
		503916 HSP7C_HUMAN (564-692): 2.3e-19: 95.1: 18.46		ANK2_HUMAN (184-667): 3.72e-25: 114: 15.43