HitPredict

Interactor 1: CCG2 (O88602)
Voltage-dependent calcium channel gamma-2 subunit (Neuronal voltage-gated calcium channel gamma-2 subunit) (Stargazin) (Transmembrane AMPAR regulatory protein gamma-2) (TARP gamma-2)
Gene: Cacng2

Interactor 2: GRIA1 (P23818)
Glutamate receptor 1 (GluR-1) (AMPA-selective glutamate receptor 1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) (GluA1)
Gene: GRIA1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	36417873, 15883194, 20805473
Identification Methods	proximity labelling technology, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Lig_chan~PMP22_Claudin, Lig_chan-Glu_bd~PMP22_Claudin
Common GO terms	GO:0009986 - cell surface GO:0032281 - AMPA glutamate receptor complex GO:0035255 - ionotropic glutamate receptor binding GO:0036477 - somatodendritic compartment GO:0098839 - postsynaptic density membrane and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 323 Mm			1 907
+	Rn
		585154 CCG2_RAT (1-323): 4.83e-141: 403: 100.00		GRIA1_RAT (1-907): 0: 939: 98.90
+	Hs
		786719 CCG2_HUMAN (1-323): 2.11e-140: 401: 98.76		GRIA1_HUMAN (1-907): 0: 931: 97.69
+	Mm
		620910 CCG3_MOUSE (1-323): 6.86e-122: 354: 70.90		GRIA1_MOUSE (1-907): 0: 939: 100.00
+	Hs
		816230 CCG2_HUMAN (1-323): 2.11e-140: 401: 98.76		GRIA4_HUMAN (7-907): 0: 848: 67.07
+	Rn
		585156 CCG8_RAT (4-323): 1.4e-98: 298: 44.50		GRIA1_RAT (1-907): 0: 939: 98.90
+	Mm
		291990 CCG2_MOUSE (1-323): 4.83e-141: 403: 100.00		GRIA2_MOUSE (6-840): 0: 829: 70.71
+	Hs
		786752 CCG2_HUMAN (1-323): 2.11e-140: 401: 98.76		GRIA2_HUMAN (6-840): 0: 831: 70.83
+	Rn
		585177 CCG2_RAT (1-323): 4.83e-141: 403: 100.00		GRIA2_RAT (6-840): 0: 828: 70.71
+	Rn
		585181 Q99PR9_RAT (1-323): 4.78e-141: 403: 99.69		GRIA2_RAT (6-840): 0: 828: 70.71
+	Hs
		786706 CCG8_HUMAN (4-323): 5.92e-95: 289: 46.73		GRIA1_HUMAN (1-907): 0: 931: 97.69
+	Mm
		621048 CCG3_MOUSE (1-323): 6.86e-122: 354: 70.90		GRIA2_MOUSE (6-840): 0: 829: 70.71
+	Rn
		585179 CCG8_RAT (4-323): 1.4e-98: 298: 44.50		GRIA2_RAT (6-840): 0: 828: 70.71
+	Mm
		621016 CCG8_MOUSE (4-323): 2.03e-97: 295: 44.04		GRIA2_MOUSE (6-840): 0: 829: 70.71
+	Ce
		106308 G5EDT2_CAEEL (1-321): 1.59e-93: 284: 19.24		GLR1_CAEEL (2-882): 0: 597: 34.61