HitPredict

Interactor 1: SH21A (O88890)
SH2 domain-containing protein 1A (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
Gene: Sh2d1a

Interactor 2: FYN (P39688)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene c-Fyn) (p59-Fyn)
Gene: FYN

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	12545173, 16847311
Identification Methods	pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0002250 - adaptive immune response
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 126 Mm			1 537
+	Hs
		411545 LCK_HUMAN (1-124): 8.45e-41: 143: 20.77		FYN_HUMAN (1-537): 0: 634: 99.44
+	Hs
		411573 LCK_HUMAN (1-124): 8.45e-41: 143: 20.77		SRC_HUMAN (1-537): 0: 592: 68.76
+	Hs
		442772 HCK_HUMAN (1-124): 7.39e-41: 143: 22.31		SRC_HUMAN (1-537): 0: 592: 68.76
+	Rn
		989767 LYN_RAT (1-124): 2.66e-39: 139: 19.23		SRC_RAT (1-537): 0: 594: 68.33
+	Hs
		411552 LCK_HUMAN (1-124): 8.45e-41: 143: 20.77		YES_HUMAN (1-537): 0: 581: 72.16
+	Hs
		442759 HCK_HUMAN (1-124): 7.39e-41: 143: 22.31		HCK_HUMAN (1-535): 0: 571: 56.26
+	Mm
		435875 HCK_MOUSE (1-124): 1.6e-40: 142: 21.54		HCK_MOUSE (1-535): 0: 555: 55.70
+	Hs
		411544 LCK_HUMAN (1-124): 8.45e-41: 143: 20.77		LCK_HUMAN (74-535): 0: 547: 61.04
+	Hs
		411559 HCK_HUMAN (1-124): 7.39e-41: 143: 22.31		LCK_HUMAN (74-535): 0: 547: 61.04
+	Hs
		411553 LCK_HUMAN (1-124): 8.45e-41: 143: 20.77		LYN_HUMAN (1-535): 0: 535: 54.48
+	Hs
		433530 HCK_HUMAN (1-124): 7.39e-41: 143: 22.31		LYN_HUMAN (1-535): 0: 535: 54.48
+	Hs
		176351 SHIP2_HUMAN (3-120): 7.95e-40: 142: 42.37		LYN_HUMAN (1-535): 0: 535: 54.48
+	Rn
		989763 LYN_RAT (1-124): 2.66e-39: 139: 19.23		LYN_RAT (1-535): 0: 533: 53.92
+	Hs
		69199 SHIP2_HUMAN (3-120): 7.95e-40: 142: 42.37		A9UF07_HUMAN (3-537): 5.45e-166: 516: 37.66
+	Hs
		442789 HCK_HUMAN (1-124): 7.39e-41: 143: 22.31		ABL2_HUMAN (7-537): 4.66e-170: 514: 38.27
+	Hs
		411648 LCK_HUMAN (1-124): 8.45e-41: 143: 20.77		BLK_HUMAN (24-535): 7.18e-178: 512: 55.75
+	Hs
		337315 HCK_HUMAN (1-124): 7.39e-41: 143: 22.31		ABL1_HUMAN (43-537): 2.63e-169: 510: 39.84
+	Hs
		176332 SHIP2_HUMAN (3-120): 7.95e-40: 142: 42.37		ABL1_HUMAN (43-537): 2.63e-169: 510: 39.84
+	Hs
		442813 HCK_HUMAN (1-124): 7.39e-41: 143: 22.31		BTK_HUMAN (5-531): 6.51e-169: 495: 33.59