HitPredict

Interactor 1: HDAC3 (O88895)
Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-)
Gene: HDAC3

Interactor 2: NR2E1 (Q64104)
Nuclear receptor subfamily 2 group E member 1 (Nuclear receptor TLX) (Protein tailless homolog) (Tll) (mTll)
Gene: NR2E1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	17873065
Identification Methods	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0042826 - histone deacetylase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 428 Mm			1 385
+	Hs
		177412 HDAC3_HUMAN (1-428): 0: 610: 99.77		NR2E1_HUMAN (1-385): 2.95e-135: 393: 98.96
+	Hs
		1038843 HDAC1_HUMAN (3-385): 0: 591: 63.19		NR2E1_HUMAN (1-385): 2.95e-135: 393: 98.96
+	Hs
		1270541 HDAC2_HUMAN (3-422): 0: 582: 58.87		NR2E1_HUMAN (1-385): 2.95e-135: 393: 98.96
+	Hs
		177191 HDAC3_HUMAN (1-428): 0: 610: 99.77		RXRA_HUMAN (2-383): 4.32e-111: 334: 30.89
+	Mm
		140236 HDAC1_MOUSE (3-385): 0: 591: 63.19		RXRA_MOUSE (2-383): 4.9e-112: 337: 30.89
+	Hs
		177166 HDAC3_HUMAN (1-428): 0: 610: 99.77		ESR1_HUMAN (8-385): 5.17e-96: 300: 29.06
+	Hs
		177223 HDAC3_HUMAN (1-428): 0: 610: 99.77		HNF4A_HUMAN (2-383): 1.93e-95: 294: 29.90
+	Hs
		622790 HDAC1_HUMAN (3-385): 0: 591: 63.19		COT2_HUMAN (5-383): 6.2e-102: 309: 34.83
+	Hs
		611437 HDAC1_HUMAN (3-385): 0: 591: 63.19		NR4A1_HUMAN (4-383): 1.24e-98: 307: 26.44
+	Hs
		369550 HDAC1_HUMAN (3-385): 0: 591: 63.19		ESR1_HUMAN (8-385): 5.17e-96: 300: 29.06
+	Hs
		177175 HDAC3_HUMAN (1-428): 0: 610: 99.77		RARA_HUMAN (14-384): 4.2e-89: 278: 25.34
+	Hs
		177343 HDAC3_HUMAN (1-428): 0: 610: 99.77		ESR2_HUMAN (2-382): 2.78e-88: 278: 26.75
+	Hs
		370134 HDAC2_HUMAN (3-422): 0: 582: 58.87		ESR1_HUMAN (8-385): 5.17e-96: 300: 29.06
+	Hs
		1038589 HDAC1_HUMAN (3-385): 0: 591: 63.19		ESR2_HUMAN (2-382): 2.78e-88: 278: 26.75
+	Mm
		140277 HDAC1_MOUSE (3-385): 0: 591: 63.19		ERR2_MOUSE (9-383): 9.17e-90: 278: 28.53
+	Hs
		487964 HDAC1_HUMAN (3-385): 0: 591: 63.19		RARA_HUMAN (14-384): 4.2e-89: 278: 25.34
+	Hs
		1269273 HDAC2_HUMAN (3-422): 0: 582: 58.87		ESR2_HUMAN (2-382): 2.78e-88: 278: 26.75
+	Hs
		488000 HDAC2_HUMAN (3-422): 0: 582: 58.87		RARA_HUMAN (14-384): 4.2e-89: 278: 25.34
+	Mm
		936400 HDAC2_MOUSE (3-422): 0: 580: 58.63		ERR2_MOUSE (9-383): 9.17e-90: 278: 28.53
+	Mm
		139250 HDAC8_MOUSE (6-367): 1.43e-144: 418: 42.27		ERR1_MOUSE (16-382): 3.98e-35: 135: 30.40