HitPredict

Interactor 1: GRB14 (O88900)
Growth factor receptor-bound protein 14 (GRB14 adapter protein)
Gene: GRB14

Interactor 2: T2CB11 (T2CB11)
Tyrosine-protein kinase receptor (EC 2.7.10.1)
Gene: Insr

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	25687571
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BPS~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, SH2~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 538 Rn			1 1384
+	Rn
		292431 GRB14_RAT (1-538): 0: 651: 100.00		INSR_RAT (1-1384): 0: 1550: 99.49
+	Hs
		411383 GRB14_HUMAN (1-538): 0: 629: 85.00		INSR_HUMAN (28-1384): 0: 1509: 95.65
+	Hs
		411376 GRB10_HUMAN (5-538): 0: 537: 52.71		INSR_HUMAN (28-1384): 0: 1509: 95.65
+	Hs
		411384 GRB7_HUMAN (33-538): 3.72e-166: 483: 47.29		INSR_HUMAN (28-1384): 0: 1509: 95.65
+	Hs
		435642 GRB14_HUMAN (1-538): 0: 629: 85.00		IGF1R_HUMAN (18-1382): 0: 1292: 56.08
+	Hs
		435632 GRB10_HUMAN (5-538): 0: 537: 52.71		IGF1R_HUMAN (18-1382): 0: 1292: 56.08
+	Hs
		872640 GRB10_HUMAN (5-538): 0: 537: 52.71		EPHA4_HUMAN (663-1329): 1.63e-179: 560: 23.94
+	Hs
		872612 GRB10_HUMAN (5-538): 0: 537: 52.71		EPHB1_HUMAN (662-1322): 1.4e-170: 537: 24.31
+	Hs
		872614 GRB7_HUMAN (33-538): 3.72e-166: 483: 47.29		EPHB1_HUMAN (662-1322): 1.4e-170: 537: 24.31
+	Hs
		383805 GRB14_HUMAN (1-538): 0: 629: 85.00		ERBB2_HUMAN (931-1383): 6.22e-89: 318: 23.48
+	Hs
		383780 GRB10_HUMAN (5-538): 0: 537: 52.71		ERBB2_HUMAN (931-1383): 6.22e-89: 318: 23.48
+	Hs
		383806 GRB7_HUMAN (33-538): 3.72e-166: 483: 47.29		ERBB2_HUMAN (931-1383): 6.22e-89: 318: 23.48
+	Hs
		1031671 GRB10_HUMAN (5-538): 0: 537: 52.71		NTRK2_HUMAN (998-1294): 2.07e-67: 246: 42.72
+	Hs
		338431 GRB14_HUMAN (1-538): 0: 629: 85.00		EGFR_HUMAN (31-309): 2.68e-30: 132: 22.36
+	Hs
		338370 GRB10_HUMAN (5-538): 0: 537: 52.71		EGFR_HUMAN (31-309): 2.68e-30: 132: 22.36
+	Hs
		383927 Q96D37_HUMAN (102-532): 2.6e-95: 308: 16.83		ERBB2_HUMAN (931-1383): 6.22e-89: 318: 23.48
+	Hs
		338432 GRB7_HUMAN (33-538): 3.72e-166: 483: 47.29		EGFR_HUMAN (31-309): 2.68e-30: 132: 22.36
+	Hs
		601921 GRB7_HUMAN (33-538): 3.72e-166: 483: 47.29		ERBB3_HUMAN (26-369): 2.81e-29: 129: 19.42
+	Hs
		338823 Q96D37_HUMAN (102-532): 2.6e-95: 308: 16.83		EGFR_HUMAN (31-309): 2.68e-30: 132: 22.36
+	Mm
		654977 VAV_MOUSE (83-532): 1.38e-96: 313: 17.14		EGFR_MOUSE (31-305): 1.41e-27: 123: 23.66