HitPredict

Interactor 1: KCNQ2 (O88943)
Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2)
Gene: KCNQ2

Interactor 2: NEDD4 (Q62940)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase NEDD4)
Gene: NEDD4

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17322297
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0042391 - regulation of membrane potential
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 852 Rn			1 887
+	Hs
		1058646 KCNB1_HUMAN (20-761): 7.05e-115: 372: 16.03		NED4L_HUMAN (58-887): 0: 770: 56.21
+	Hs
		850267 KCNQ1_HUMAN (46-678): 4.28e-105: 340: 34.75		NED4L_HUMAN (58-887): 0: 770: 56.21
+	Hs
		602911 KCNA3_HUMAN (47-328): 1.58e-98: 320: 20.69		NED4L_HUMAN (58-887): 0: 770: 56.21
+	Hs
		808053 KCNQ1_HUMAN (46-678): 4.28e-105: 340: 34.75		NEDD4_HUMAN (154-887): 0: 724: 78.86
+	Mm
		808378 SCN5A_MOUSE (1-247): 7.16e-21: 100: 15.12		NEDD4_MOUSE (1-887): 0: 910: 94.59
+	Mm
		808381 SCN8A_MOUSE (17-247): 9.35e-21: 100: 15.12		NEDD4_MOUSE (1-887): 0: 910: 94.59
+	Mm
		808363 SCNAA_MOUSE (4-247): 1.27e-19: 97.1: 13.39		NEDD4_MOUSE (1-887): 0: 910: 94.59
+	Hs
		1047217 CAC1C_HUMAN (3-256): 1.6e-30: 132: 14.97		NED4L_HUMAN (58-887): 0: 770: 56.21
+	Hs
		1055040 SCN5A_HUMAN (2-247): 1.69e-20: 99.8: 15.14		NED4L_HUMAN (58-887): 0: 770: 56.21
+	Hs
		808322 SCN8A_HUMAN (17-524): 7.69e-22: 104: 11.91		NEDD4_HUMAN (154-887): 0: 724: 78.86
+	Hs
		808128 SCN5A_HUMAN (2-247): 1.69e-20: 99.8: 15.14		NEDD4_HUMAN (154-887): 0: 724: 78.86
+	Hs
		723839 SCN1A_HUMAN (5-247): 5.62e-20: 98.2: 10.98		NEDD4_HUMAN (154-887): 0: 724: 78.86
+	Hs
		125445 CAC1C_HUMAN (3-256): 1.6e-30: 132: 14.97		WWP2_HUMAN (72-884): 0: 677: 33.30
+	Hs
		125457 SCN5A_HUMAN (2-247): 1.69e-20: 99.8: 15.14		WWP2_HUMAN (72-884): 0: 677: 33.30
+	Hs
		1055045 SCN5A_HUMAN (2-247): 1.69e-20: 99.8: 15.14		SMUF2_HUMAN (76-883): 0: 657: 34.19
+	Hs
		723851 SCN1A_HUMAN (5-247): 5.62e-20: 98.2: 10.98		SMUF2_HUMAN (76-883): 0: 657: 34.19
+	Mm
		93283 SCN5A_MOUSE (1-247): 7.16e-21: 100: 15.12		E9PXB7_MOUSE (169-887): 0: 651: 57.16
+	Mm
		93284 SCN8A_MOUSE (17-247): 9.35e-21: 100: 15.12		E9PXB7_MOUSE (169-887): 0: 651: 57.16
+	Mm
		93276 SCNAA_MOUSE (4-247): 1.27e-19: 97.1: 13.39		E9PXB7_MOUSE (169-887): 0: 651: 57.16
+	Mm
		93274 SCN9A_MOUSE (9-656): 5.13e-19: 95.2: 10.30		E9PXB7_MOUSE (169-887): 0: 651: 57.16