HitPredict

Interactor 1: GRAP2 (O89100)
GRB2-related adaptor protein 2 (Adapter protein GRID) (GADS protein) (GRB-2-like protein) (GRB2L) (GRB-2-related monocytic adapter protein) (MONA) (Monocytic adapter) (GRBLG) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adaptor protein GrpL)
Gene: GRAP2

Interactor 2: CSF1R (P09581)
Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115)
Gene: CSF1R

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	1.00	0.680

Property	Details
Experiments	9857184
Identification Methods	two hybrid, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005654 - nucleoplasm GO:0005886 - plasma membrane GO:0043408 - regulation of MAPK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 322 Mm			1 977
+	Hs
		275162 GRAP2_HUMAN (1-322): 7.19e-63: 204: 72.42		CSF1R_HUMAN (1-977): 0: 698: 74.16
+	Hs
		426976 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		CSF1R_HUMAN (1-977): 0: 698: 74.16
+	Mm
		452188 PLCG2_MOUSE (9-321): 1.66e-31: 126: 17.05		CSF1R_MOUSE (1-977): 0: 752: 100.00
+	Mm
		292679 GRAP2_MOUSE (1-322): 4.39e-68: 217: 100.00		KIT_MOUSE (4-960): 0: 599: 36.11
+	Rn
		595729 LYN_RAT (3-136): 1.38e-55: 190: 31.76		PGFRA_RAT (1-908): 2.75e-179: 551: 31.28
+	Hs
		337317 ABL1_HUMAN (4-136): 1.18e-50: 182: 35.71		PGFRB_HUMAN (22-971): 1.69e-168: 523: 31.96
+	Hs
		433624 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		FLT3_HUMAN (10-952): 2.13e-164: 509: 30.92
+	Hs
		337376 ABL1_HUMAN (4-136): 1.18e-50: 182: 35.71		FLT3_HUMAN (10-952): 2.13e-164: 509: 30.92
+	Hs
		738179 BLK_HUMAN (3-146): 7.8e-53: 182: 28.66		FLT3_HUMAN (10-952): 2.13e-164: 509: 30.92
+	Mm
		93303 E9PYG6_MOUSE (51-147): 3.5e-19: 90.4: 29.13		PGFRB_MOUSE (22-971): 2.06e-172: 533: 32.26
+	Hs
		433573 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		FGFR2_HUMAN (4-311): 4.13e-56: 210: 14.61
+	Hs
		433576 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		FGFR4_HUMAN (93-414): 1.23e-34: 144: 16.29
+	Dm
		112243 CRK_DROME (48-320): 8.25e-48: 163: 20.94		M9MRE1_DROME (19-490): 8.16e-39: 159: 17.96
+	Hs
		275165 GRAP2_HUMAN (1-322): 7.19e-63: 204: 72.42		KIT_HUMAN (174-518): 1.37e-11: 71: 11.73
+	Hs
		433742 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		PTK7_HUMAN (2-113): 9.18e-13: 74.8: 14.40
+	Hs
		433539 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		KIT_HUMAN (174-518): 1.37e-11: 71: 11.73
+	Hs
		337322 ABL1_HUMAN (4-136): 1.18e-50: 182: 35.71		KIT_HUMAN (174-518): 1.37e-11: 71: 11.73
+	Hs
		499249 BLK_HUMAN (3-146): 7.8e-53: 182: 28.66		KIT_HUMAN (174-518): 1.37e-11: 71: 11.73
+	Hs
		507835 PLCG2_HUMAN (9-321): 5.88e-33: 130: 18.21		FGFR1_HUMAN (32-209): 3.67e-23: 107: 14.22
+	Hs
		499228 PLCG2_HUMAN (9-321): 5.88e-33: 130: 18.21		KIT_HUMAN (174-518): 1.37e-11: 71: 11.73