HitPredict

Interactor 1: GRAP2 (O89100)
GRB2-related adaptor protein 2 (Adapter protein GRID) (GADS protein) (GRB-2-like protein) (GRB2L) (GRB-2-related monocytic adapter protein) (MONA) (Monocytic adapter) (GRBLG) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adaptor protein GrpL)
Gene: GRAP2

Interactor 2: SHC1 (P98083)
SHC-transforming protein 1 (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9872323
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~SH3_1
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 322 Mm			1 579
+	Hs
		433604 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		SHC1_HUMAN (1-579): 5.04e-179: 520: 94.17
+	Hs
		337362 ABL1_HUMAN (4-136): 1.18e-50: 182: 35.71		SHC1_HUMAN (1-579): 5.04e-179: 520: 94.17
+	Hs
		275520 ABL1_HUMAN (4-136): 1.18e-50: 182: 35.71		BCAR3_HUMAN (349-579): 5.99e-47: 178: 20.70
+	Hs
		433546 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		SRC_HUMAN (334-570): 7.45e-44: 166: 16.87
+	Rn
		989767 LYN_RAT (3-136): 1.38e-55: 190: 31.76		SRC_RAT (334-570): 1.36e-42: 162: 16.80
+	Hs
		433893 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		SH2D3_HUMAN (333-578): 1.56e-40: 159: 22.75
+	Hs
		337329 ABL1_HUMAN (4-136): 1.18e-50: 182: 35.71		SRC_HUMAN (334-570): 7.45e-44: 166: 16.87
+	Mm
		763401 Q91YX7_MOUSE (5-187): 7.24e-55: 192: 23.98		FYN_MOUSE (367-579): 2.26e-40: 156: 18.86
+	Hs
		433653 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		BLK_HUMAN (362-577): 2.17e-40: 155: 18.14
+	Hs
		433775 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		SHB_HUMAN (385-575): 1.72e-39: 153: 22.66
+	Hs
		337337 ABL1_HUMAN (4-136): 1.18e-50: 182: 35.71		NCK1_HUMAN (360-571): 3.06e-42: 157: 19.37
+	Hs
		337307 ABL1_HUMAN (4-136): 1.18e-50: 182: 35.71		FYN_HUMAN (367-579): 2.26e-40: 156: 18.86
+	Hs
		433595 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		P85A_HUMAN (479-575): 6.35e-19: 92.7: 24.75
+	Hs
		275185 GRAP2_HUMAN (1-322): 7.19e-63: 204: 72.42		GRB2_HUMAN (478-574): 1.33e-15: 77.9: 30.48
+	Mm
		557349 BLK_MOUSE (3-146): 2.52e-55: 189: 30.57		P85A_MOUSE (479-575): 6.35e-19: 92.7: 24.75
+	Mm
		639435 LYN_MOUSE (3-136): 1.95e-55: 189: 31.76		P85A_MOUSE (479-575): 6.35e-19: 92.7: 24.75
+	Hs
		129169 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		P85B_HUMAN (479-576): 2.03e-18: 91.2: 23.53
+	Hs
		337356 ABL1_HUMAN (4-136): 1.18e-50: 182: 35.71		P85A_HUMAN (479-575): 6.35e-19: 92.7: 24.75
+	Hs
		129151 ABL1_HUMAN (4-136): 1.18e-50: 182: 35.71		P85B_HUMAN (479-576): 2.03e-18: 91.2: 23.53
+	Hs
		337418 ABL1_HUMAN (4-136): 1.18e-50: 182: 35.71		GRB2_HUMAN (478-574): 1.33e-15: 77.9: 30.48