HitPredict

Interactor 1: GRAP2 (O89100)
GRB2-related adaptor protein 2 (Adapter protein GRID) (GADS protein) (GRB-2-like protein) (GRB2L) (GRB-2-related monocytic adapter protein) (MONA) (Monocytic adapter) (GRBLG) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adaptor protein GrpL)
Gene: GRAP2

Interactor 2: LCP2 (Q60787)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	15668918, 24584089
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 322 Mm			1 533
+	Hs
		275193 GRAP2_HUMAN (1-322): 7.19e-63: 204: 72.42		LCP2_HUMAN (1-531): 2.21e-75: 249: 80.98
+	Hs
		433736 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		LCP2_HUMAN (1-531): 2.21e-75: 249: 80.98
+	Mm
		292689 GRAP2_MOUSE (1-322): 4.39e-68: 217: 100.00		BLNK_MOUSE (52-520): 1.69e-35: 140: 21.62
+	Hs
		275217 GRAP2_HUMAN (1-322): 7.19e-63: 204: 72.42		BLNK_HUMAN (52-520): 3.13e-36: 142: 22.80
+	Hs
		433917 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		BLNK_HUMAN (52-520): 3.13e-36: 142: 22.80
+	Mm
		639462 LYN_MOUSE (3-136): 1.95e-55: 189: 31.76		CLNK_MOUSE (170-528): 4.86e-35: 138: 25.20
+	Hs
		297808 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		K0754_HUMAN (35-471): 1.85e-27: 119: 12.92
+	Hs
		433853 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		MICA3_HUMAN (54-405): 3.78e-26: 115: 12.64
+	Hs
		433891 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		MINK1_HUMAN (115-411): 2.89e-21: 100: 14.98
+	Hs
		562659 PLCG2_HUMAN (9-321): 5.88e-33: 130: 18.21		BLNK_HUMAN (52-520): 3.13e-36: 142: 22.80
+	Hs
		433560 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		MUC1_HUMAN (92-442): 2.35e-14: 78.2: 11.55
+	Mm
		1208607 PLCG2_MOUSE (9-321): 1.66e-31: 126: 17.05		BLNK_MOUSE (52-520): 1.69e-35: 140: 21.62
+	Hs
		337335 ABL1_HUMAN (4-136): 1.18e-50: 182: 35.71		MUC1_HUMAN (92-442): 2.35e-14: 78.2: 11.55
+	Hs
		782797 CSK_HUMAN (2-164): 1.48e-37: 141: 25.00		TENS3_HUMAN (52-512): 1.47e-26: 116: 12.63
+	Hs
		782795 CSK_HUMAN (2-164): 1.48e-37: 141: 25.00		TENS2_HUMAN (86-512): 5.89e-22: 102: 15.79
+	Hs
		782828 CSK_HUMAN (2-164): 1.48e-37: 141: 25.00		TENS1_HUMAN (65-512): 5.51e-21: 99.4: 13.11
+	Hs
		203191 VINEX_HUMAN (33-320): 1.64e-17: 85: 14.33		SYNJ1_HUMAN (10-467): 2.51e-29: 125: 9.82
+	Hs
		235523 VINEX_HUMAN (33-320): 1.64e-17: 85: 14.33		TENS2_HUMAN (86-512): 5.89e-22: 102: 15.79
+	Hs
		235595 VINEX_HUMAN (33-320): 1.64e-17: 85: 14.33		TENS1_HUMAN (65-512): 5.51e-21: 99.4: 13.11
+	Hs
		596434 RASA1_HUMAN (51-147): 7.18e-19: 89.3: 29.13		MAGE1_HUMAN (93-480): 3.27e-09: 61.7: 10.54