HitPredict

Interactor 1: GRAP2 (O89100)
GRB2-related adaptor protein 2 (Adapter protein GRID) (GADS protein) (GRB-2-like protein) (GRB2L) (GRB-2-related monocytic adapter protein) (MONA) (Monocytic adapter) (GRBLG) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adaptor protein GrpL)
Gene: GRAP2

Interactor 2: PTN23 (Q6PB44)
Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48)
Gene: Ptpn23

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.51	1.00	0.716

Property	Details
Experiments	19523899
Identification Methods	x-ray crystallography, peptide array, isothermal titration calorimetry
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	SH2~Y_phosphatase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005768 - endosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 322 Mm			1 1692
+	Hs
		275227 GRAP2_HUMAN (1-322): 7.19e-63: 204: 72.42		PTN23_HUMAN (1-1692): 0: 949: 81.28
+	Mm
		1208610 PLCG2_MOUSE (9-321): 1.66e-31: 126: 17.05		PDC6I_MOUSE (9-879): 1.66e-177: 558: 22.79
+	Mm
		639436 LYN_MOUSE (3-136): 1.95e-55: 189: 31.76		PTN6_MOUSE (1185-1523): 2.87e-127: 413: 25.14
+	Hs
		337339 ABL1_HUMAN (4-136): 1.18e-50: 182: 35.71		PTN1_HUMAN (1232-1626): 6.88e-124: 397: 24.51
+	Hs
		433603 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		PTN6_HUMAN (1186-1538): 1.34e-112: 372: 23.78
+	Hs
		337361 ABL1_HUMAN (4-136): 1.18e-50: 182: 35.71		PTN6_HUMAN (1186-1538): 1.34e-112: 372: 23.78
+	Hs
		782777 CSK_HUMAN (2-164): 1.48e-37: 141: 25.00		PTN12_HUMAN (1225-1619): 1.4e-116: 389: 23.82
+	Mm
		782850 CSK_MOUSE (2-164): 2.24e-37: 140: 26.14		PTN18_MOUSE (1256-1631): 1.86e-111: 363: 24.48
+	Hs
		562628 PLCG2_HUMAN (9-321): 5.88e-33: 130: 18.21		PTN6_HUMAN (1186-1538): 1.34e-112: 372: 23.78
+	Hs
		789088 ABL2_HUMAN (5-136): 2.01e-17: 85.1: 36.69		PTN18_HUMAN (1246-1632): 3.36e-118: 383: 24.63
+	Dm
		337644 ABL_DROME (5-132): 1.13e-17: 85.9: 38.97		LAR_DROME (1228-1509): 3.05e-94: 341: 28.32
+	Hs
		433579 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		PTPRG_HUMAN (1265-1542): 5.63e-40: 165: 24.40
+	Hs
		782790 CSK_HUMAN (2-164): 1.48e-37: 141: 25.00		PTPRK_HUMAN (1240-1511): 5.96e-53: 207: 21.94
+	Hs
		337358 ABL1_HUMAN (4-136): 1.18e-50: 182: 35.71		PTN4_HUMAN (1276-1511): 3.74e-29: 129: 33.33
+	Mm
		337619 ABL1_MOUSE (4-136): 8.46e-51: 182: 35.71		PTN11_MOUSE (1251-1515): 1.94e-29: 127: 31.69
+	Hs
		617084 CSK_HUMAN (2-164): 1.48e-37: 141: 25.00		PTPRG_HUMAN (1265-1542): 5.63e-40: 165: 24.40
+	Hs
		616905 CSK_HUMAN (2-164): 1.48e-37: 141: 25.00		PTPRB_HUMAN (1276-1505): 1.83e-29: 130: 33.19
+	Hs
		562641 PLCG2_HUMAN (9-321): 5.88e-33: 130: 18.21		PTN11_HUMAN (1251-1515): 2.3e-29: 127: 31.69
+	Dm
		337647 ABL_DROME (5-132): 1.13e-17: 85.9: 38.97		PTP99_DROME (1236-1537): 1.85e-34: 146: 19.75
+	Dm
		337661 ABL_DROME (5-132): 1.13e-17: 85.9: 38.97		PTP61_DROME (1256-1512): 4.31e-31: 132: 32.18