HitPredict

Interactor 1: GRAP2 (O89100)
GRB2-related adaptor protein 2 (Adapter protein GRID) (GADS protein) (GRB-2-like protein) (GRB2L) (GRB-2-related monocytic adapter protein) (MONA) (Monocytic adapter) (GRBLG) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adaptor protein GrpL)
Gene: GRAP2

Interactor 2: UBP8 (Q80U87)
Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (mUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8)
Gene: Usp8

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	12176364
Identification Methods	lambda phage display, filter binding
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 322 Mm			1 1080
+	Hs
		275176 GRAP2_HUMAN (1-322): 7.19e-63: 204: 72.42		UBP8_HUMAN (1-1080): 0: 679: 80.86
+	Mm
		1141140 GRB2_MOUSE (3-53): 2.31e-11: 64.2: 30.77		UBP8_MOUSE (1-1080): 0: 721: 100.00
+	Hs
		522830 SRC_HUMAN (192-319): 5.01e-16: 80.6: 24.62		UBP8_HUMAN (1-1080): 0: 679: 80.86
+	Hs
		777028 GRB2_HUMAN (3-53): 1.98e-11: 64.6: 30.77		UBP8_HUMAN (1-1080): 0: 679: 80.86
+	Hs
		846546 BLK_HUMAN (3-146): 7.8e-53: 182: 28.66		UBP22_HUMAN (707-1071): 3.6e-108: 349: 26.80
+	Hs
		64203 BLK_HUMAN (3-146): 7.8e-53: 182: 28.66		UBP27_HUMAN (707-1080): 3.02e-105: 338: 25.24
+	Hs
		235455 VINEX_HUMAN (33-320): 1.64e-17: 85: 14.33		UBP2_HUMAN (678-1073): 1.79e-113: 366: 36.66
+	Hs
		523210 SRC_HUMAN (192-319): 5.01e-16: 80.6: 24.62		UBP22_HUMAN (707-1071): 3.6e-108: 349: 26.80
+	Hs
		259274 GRB2_HUMAN (3-53): 1.98e-11: 64.6: 30.77		UBP12_HUMAN (701-1072): 2.62e-107: 341: 25.71
+	Hs
		64216 SH3K1_HUMAN (3-61): 7.41e-11: 65: 27.42		UBP27_HUMAN (707-1080): 3.02e-105: 338: 25.24
+	Hs
		1174027 SH3K1_HUMAN (3-61): 7.41e-11: 65: 27.42		UBP51_HUMAN (691-1076): 8.75e-100: 332: 23.64
+	Hs
		522952 SRC_HUMAN (192-319): 5.01e-16: 80.6: 24.62		UBP4_HUMAN (926-1068): 5.76e-33: 140: 44.06
+	Hs
		802832 CRKL_HUMAN (245-322): 7.5e-13: 69.8: 24.05		UBP4_HUMAN (926-1068): 5.76e-33: 140: 44.06
+	Hs
		411649 LCK_HUMAN (255-321): 4.38e-10: 62.5: 24.64		UBP11_HUMAN (926-1068): 8.78e-34: 142: 44.90
+	Hs
		523072 SRC_HUMAN (192-319): 5.01e-16: 80.6: 24.62		UBP32_HUMAN (919-1004): 1.45e-14: 80.9: 42.53