HitPredict

Interactor 1: GRAP2 (O89100)
GRB2-related adaptor protein 2 (Adapter protein GRID) (GADS protein) (GRB-2-like protein) (GRB2L) (GRB-2-related monocytic adapter protein) (MONA) (Monocytic adapter) (GRBLG) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adaptor protein GrpL)
Gene: GRAP2

Interactor 2: BLNK (Q9QUN3)
B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Lymphocyte antigen 57) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65)
Gene: BLNK

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.800

Property	Details
Experiments	15102471, 12176364
Identification Methods	two hybrid, lambda phage display, filter binding
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 322 Mm			1 457
+	Hs
		275217 GRAP2_HUMAN (1-322): 7.19e-63: 204: 72.42		BLNK_HUMAN (1-457): 7.66e-74: 241: 85.56
+	Hs
		433917 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		BLNK_HUMAN (1-457): 7.66e-74: 241: 85.56
+	Mm
		1208607 PLCG2_MOUSE (9-321): 1.66e-31: 126: 17.05		BLNK_MOUSE (1-457): 2.03e-80: 258: 100.00
+	Mm
		557349 BLK_MOUSE (3-146): 2.52e-55: 189: 30.57		P85A_MOUSE (121-454): 1.52e-54: 195: 14.94
+	Mm
		639435 LYN_MOUSE (3-136): 1.95e-55: 189: 31.76		P85A_MOUSE (121-454): 1.52e-54: 195: 14.94
+	Hs
		433595 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		P85A_HUMAN (121-454): 7.04e-53: 191: 16.09
+	Hs
		337356 ABL1_HUMAN (4-136): 1.18e-50: 182: 35.71		P85A_HUMAN (121-454): 7.04e-53: 191: 16.09
+	Hs
		655277 BLK_HUMAN (3-146): 7.8e-53: 182: 28.66		P85A_HUMAN (121-454): 7.04e-53: 191: 16.09
+	Hs
		562659 PLCG2_HUMAN (9-321): 5.88e-33: 130: 18.21		BLNK_HUMAN (1-457): 7.66e-74: 241: 85.56
+	Hs
		129169 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		P85B_HUMAN (130-454): 1.76e-48: 178: 19.12
+	Hs
		129151 ABL1_HUMAN (4-136): 1.18e-50: 182: 35.71		P85B_HUMAN (130-454): 1.76e-48: 178: 19.12
+	Mm
		292686 GRAP2_MOUSE (1-322): 4.39e-68: 217: 100.00		LCP2_MOUSE (18-443): 7.45e-31: 126: 21.21
+	Hs
		275193 GRAP2_HUMAN (1-322): 7.19e-63: 204: 72.42		LCP2_HUMAN (14-443): 8.34e-34: 135: 19.61
+	Hs
		433926 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		P55G_HUMAN (328-454): 1.73e-35: 138: 26.77
+	Hs
		433736 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		LCP2_HUMAN (14-443): 8.34e-34: 135: 19.61
+	Hs
		562627 PLCG2_HUMAN (9-321): 5.88e-33: 130: 18.21		P85A_HUMAN (121-454): 7.04e-53: 191: 16.09
+	Mm
		639462 LYN_MOUSE (3-136): 1.95e-55: 189: 31.76		CLNK_MOUSE (21-444): 2.39e-33: 132: 18.62
+	Hs
		846504 BLK_HUMAN (3-146): 7.8e-53: 182: 28.66		P55G_HUMAN (328-454): 1.73e-35: 138: 26.77
+	Hs
		433891 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		MINK1_HUMAN (122-286): 9.94e-21: 97.8: 14.55
+	Hs
		297808 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		K0754_HUMAN (51-366): 1.47e-14: 78.6: 13.90