HitPredict

Interactor 1: GRAP2 (O89100)
GRB2-related adaptor protein 2 (Adapter protein GRID) (GADS protein) (GRB-2-like protein) (GRB2L) (GRB-2-related monocytic adapter protein) (MONA) (Monocytic adapter) (GRBLG) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adaptor protein GrpL)
Gene: GRAP2

Interactor 2: GAB2 (Q9Z1S8)
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (PH domain-containing adaptor molecule p97)
Gene: GAB2

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12176364
Identification Methods	lambda phage display
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 322 Mm			1 665
+	Hs
		275242 GRAP2_HUMAN (1-322): 7.19e-63: 204: 72.42		GAB2_HUMAN (4-665): 1.34e-176: 520: 90.67
+	Mm
		639464 LYN_MOUSE (3-136): 1.95e-55: 189: 31.76		GAB2_MOUSE (1-665): 2.53e-180: 529: 100.00
+	Hs
		434086 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		GAB2_HUMAN (4-665): 1.34e-176: 520: 90.67
+	Hs
		562669 PLCG2_HUMAN (9-321): 5.88e-33: 130: 18.21		GAB2_HUMAN (4-665): 1.34e-176: 520: 90.67
+	Mm
		292690 GRAP2_MOUSE (1-322): 4.39e-68: 217: 100.00		GAB1_MOUSE (5-664): 7.18e-125: 387: 36.23
+	Hs
		275195 GRAP2_HUMAN (1-322): 7.19e-63: 204: 72.42		GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71
+	Hs
		433750 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71
+	Hs
		846468 BLK_HUMAN (3-146): 7.8e-53: 182: 28.66		GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71
+	Hs
		562645 PLCG2_HUMAN (9-321): 5.88e-33: 130: 18.21		GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71
+	Hs
		433922 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		GAB3_HUMAN (1-656): 5.85e-93: 301: 31.55
+	Hs
		337512 ABL1_HUMAN (4-136): 1.18e-50: 182: 35.71		GAB3_HUMAN (1-656): 5.85e-93: 301: 31.55
+	Hs
		596400 RASA1_HUMAN (51-147): 7.18e-19: 89.3: 29.13		GAB1_HUMAN (5-664): 3.8e-125: 388: 35.71
+	Hs
		412280 FYN_HUMAN (184-320): 2.22e-16: 81.7: 24.82		GAB3_HUMAN (1-656): 5.85e-93: 301: 31.55
+	Hs
		434015 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		PKHA5_HUMAN (1-402): 1.93e-49: 188: 16.26
+	Hs
		433831 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		PKHA7_HUMAN (1-549): 2.93e-39: 157: 13.53
+	Hs
		434016 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		PKHA1_HUMAN (9-164): 6.12e-35: 139: 24.05
+	Hs
		297808 LYN_HUMAN (3-136): 6.01e-56: 190: 31.08		K0754_HUMAN (99-564): 2.73e-26: 117: 11.89
+	Hs
		203191 VINEX_HUMAN (33-320): 1.64e-17: 85: 14.33		SYNJ1_HUMAN (123-640): 1.41e-53: 201: 14.86
+	Hs
		235528 VINEX_HUMAN (33-320): 1.64e-17: 85: 14.33		PKHA7_HUMAN (1-549): 2.93e-39: 157: 13.53
+	Hs
		235546 VINEX_HUMAN (33-320): 1.64e-17: 85: 14.33		SESQ1_HUMAN (8-117): 3.45e-13: 72: 27.43