HitPredict

Interactor 1: CASP8 (O89110)
Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
Gene: CASP8

Interactor 2: TNR6 (P25446)
Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)
Gene: Fas

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.77 0.60 0.683

The method score is based on:

Property Details
Experiments 11978827, 21382479, 18455983, 17159908
Identification Methods affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0006915 - apoptotic process
GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors
GO:0031264 - death-inducing signaling complex
GO:0031265 - CD95 death-inducing signaling complex
GO:0043065 - positive regulation of apoptotic process
and 5 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 480
Mm

1 327
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024