HitPredict

Interactor 1: SMC1A (O93308)
Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1A) (xSMC1)
Gene: SMC1A

Interactor 2: Q8AW91 (Q8AW91)
Structural maintenance of chromosomes protein
Gene: smc3.L

Species: Xenopus laevis

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	10931856, 15855230
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SMC_hinge~SMC_hinge, SMC_N~SMC_N
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0016887 - ATP hydrolysis activity GO:0051301 - cell division GO:0051321 - meiotic cell cycle
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1232 Xl			1 1217
+	Mm
		1321813 SMC1A_MOUSE (1-1232): 8.04e-123: 411: 93.99		SMC3_MOUSE (1-1217): 2.26e-127: 423: 96.80
+	Hs
		1057429 SMC1A_HUMAN (1-1232): 1.59e-122: 411: 93.91		SMC3_HUMAN (1-1217): 3.79e-127: 422: 96.71
+	Bt
		333283 SMC1A_BOVIN (1-1232): 1.37e-122: 411: 93.91		SMC3_BOVIN (1-1217): 8.22e-126: 419: 95.32
+	Xl
		292725 SMC1A_XENLA (1-1232): 1.83e-119: 402: 100.00		SMC3_XENLA (1-1217): 3.66e-127: 422: 99.18
+	Hs
		1242602 SMC1B_HUMAN (1-1226): 7.16e-107: 367: 53.75		SMC3_HUMAN (1-1217): 3.79e-127: 422: 96.71
+	Mm
		1265313 SMC1B_MOUSE (1-1226): 3.45e-102: 354: 52.53		SMC3_MOUSE (1-1217): 2.26e-127: 423: 96.80
+	Hs
		1057252 SMC1A_HUMAN (1-1232): 1.59e-122: 411: 93.91		SMC1A_HUMAN (2-1211): 3.37e-79: 286: 15.88
+	Mm
		1265312 SMC1A_MOUSE (1-1232): 8.04e-123: 411: 93.99		SMC1B_MOUSE (2-1217): 1.02e-67: 252: 14.39
+	Sc
		810789 SMC4_YEAST (3-1222): 1.19e-76: 280: 19.07		SMC3_YEAST (1-1217): 4.95e-85: 304: 29.88
+	Sc
		810757 SMC3_YEAST (3-1215): 9.56e-77: 279: 18.45		SMC3_YEAST (1-1217): 4.95e-85: 304: 29.88
+	Sc
		758766 SMC4_YEAST (3-1222): 1.19e-76: 280: 19.07		SMC2_YEAST (1-1201): 3.76e-77: 280: 18.81
+	Sc
		758746 SMC3_YEAST (3-1215): 9.56e-77: 279: 18.45		SMC2_YEAST (1-1201): 3.76e-77: 280: 18.81
+	Xl
		840134 SMC4_XENLA (4-1211): 5.34e-77: 281: 20.28		SMC2_XENLA (1-1208): 1.07e-71: 264: 19.87
+	Ce
		999500 SMC4_CAEEL (4-1225): 1.22e-74: 275: 18.44		MIX1_CAEEL (1-1202): 1.98e-72: 266: 17.27
+	Sc
		700811 SMC4_YEAST (3-1222): 1.19e-76: 280: 19.07		SMC1_YEAST (2-1204): 4.31e-67: 249: 17.45
+	Sc
		700779 SMC3_YEAST (3-1215): 9.56e-77: 279: 18.45		SMC1_YEAST (2-1204): 4.31e-67: 249: 17.45