HitPredict

Interactor 1: SMC3 (O93309)
Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3)
Gene: SMC3

Interactor 2: RAD21 (O93310)
Double-strand-break repair protein rad21 homolog (SCC1 homolog) [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product)]
Gene: RAD21

Species: Xenopus laevis

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15855230
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Rad21_Rec8~SMC_N, Rad21_Rec8_N~SMC_N
Common GO terms	GO:0000775 - chromosome, centromeric region GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1209 Xl			1 629
+	Xl
		292746 Q8AW91_XENLA (1-1209): 1.41e-121: 407: 98.93		RAD21_XENLA (1-629): 0: 687: 100.00
+	Xl
		1150103 Q8AW91_XENLA (1-1209): 1.41e-121: 407: 98.93		Q6DCL7_XENLA (1-629): 0: 684: 95.39
+	Hs
		224554 SMC3_HUMAN (1-1209): 6.66e-119: 400: 95.73		RAD21_HUMAN (1-629): 0: 649: 83.15
+	Mm
		1142822 SMC3_MOUSE (1-1209): 3.68e-119: 401: 95.81		RAD21_MOUSE (1-629): 0: 643: 82.63
+	Hs
		224536 SMC4_HUMAN (1-1198): 2.48e-75: 275: 17.79		RAD21_HUMAN (1-629): 0: 649: 83.15
+	Mm
		57599 SMC3_MOUSE (1-1209): 3.68e-119: 401: 95.81		RD21L_MOUSE (1-629): 2.22e-178: 519: 40.64
+	Hs
		224434 SMC1A_HUMAN (2-1203): 1.02e-72: 267: 16.27		RAD21_HUMAN (1-629): 0: 649: 83.15
+	Mm
		1142821 SMC1A_MOUSE (2-1203): 1.02e-72: 267: 16.27		RAD21_MOUSE (1-629): 0: 643: 82.63
+	Dm
		332181 Q9VXE9_DROME (1-1209): 2.25e-103: 356: 52.15		O96689_DROME (1-628): 1.12e-164: 489: 36.53
+	Mm
		57598 SMC1A_MOUSE (2-1203): 1.02e-72: 267: 16.27		RD21L_MOUSE (1-629): 2.22e-178: 519: 40.64
+	Mm
		1207970 SMC3_MOUSE (1-1209): 3.68e-119: 401: 95.81		REC8_MOUSE (1-626): 5.24e-111: 347: 17.51
+	Hs
		304460 SMC3_HUMAN (1-1209): 6.66e-119: 400: 95.73		REC8_HUMAN (1-627): 4.6e-100: 317: 18.21
+	Sp
		193873 SMC3_SCHPO (1-1204): 4.03e-86: 307: 38.97		RAD21_SCHPO (1-623): 1.09e-115: 360: 22.96
+	Sc
		810785 SMC3_YEAST (1-1209): 1.82e-81: 293: 29.50		REC8_YEAST (23-611): 1.72e-117: 367: 15.08
+	Sp
		193874 SMC3_SCHPO (1-1204): 4.03e-86: 307: 38.97		REC8_SCHPO (1-621): 1.16e-105: 332: 15.86
+	Sp
		293280 SMC1_SCHPO (2-1196): 3.88e-73: 268: 15.69		RAD21_SCHPO (1-623): 1.09e-115: 360: 22.96
+	Sp
		293281 SMC1_SCHPO (2-1196): 3.88e-73: 268: 15.69		REC8_SCHPO (1-621): 1.16e-105: 332: 15.86
+	Hs
		304438 SMC1A_HUMAN (2-1203): 1.02e-72: 267: 16.27		REC8_HUMAN (1-627): 4.6e-100: 317: 18.21
+	Sc
		810784 SMC3_YEAST (1-1209): 1.82e-81: 293: 29.50		SCC1_YEAST (7-627): 2.19e-89: 290: 17.55
+	Sc
		758764 SMC2_YEAST (1-1193): 6.68e-76: 276: 18.72		SCC1_YEAST (7-627): 2.19e-89: 290: 17.55