HitPredict

Interactor 1: SMC3 (O93309)
Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3)
Gene: SMC3

Interactor 2: PD5BB (Q5U241)
Sister chromatid cohesion protein PDS5 homolog B-B (Androgen-induced proliferation inhibitor B)
Gene: pds5b-b

Species: Xenopus laevis

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15855230
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0006281 - DNA repair GO:0007064 - mitotic sister chromatid cohesion GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1209 Xl			1 1464
+	Xl
		292738 SMC3_XENLA (1-1209): 6.91e-124: 413: 100.00		PD5BA_XENLA (1-1449): 0: 1518: 95.86
+	Xl
		1115499 Q8AW91_XENLA (1-1209): 1.41e-121: 407: 98.93		PD5BA_XENLA (1-1449): 0: 1518: 95.86
+	Hs
		1345702 SMC3_HUMAN (1-1209): 6.66e-119: 400: 95.73		PDS5B_HUMAN (1-1424): 0: 1485: 85.14
+	Hs
		1100586 SMC3_HUMAN (1-1209): 6.66e-119: 400: 95.73		PDS5A_HUMAN (2-1350): 0: 1448: 67.21
+	Mm
		93885 SMC3_MOUSE (1-1209): 3.68e-119: 401: 95.81		E9QPI5_MOUSE (2-1350): 0: 1438: 67.33
+	Xl
		292739 SMC3_XENLA (1-1209): 6.91e-124: 413: 100.00		PD5AA_XENLA (4-1349): 0: 1405: 66.89
+	Xl
		1117310 Q8AW91_XENLA (1-1209): 1.41e-121: 407: 98.93		PD5AB_XENLA (13-1349): 0: 1406: 67.24
+	Hs
		1057405 SMC1A_HUMAN (2-1203): 1.02e-72: 267: 16.27		PDS5B_HUMAN (1-1424): 0: 1485: 85.14
+	Mm
		1118817 SMC1A_MOUSE (2-1203): 1.02e-72: 267: 16.27		PDS5B_MOUSE (1-1427): 0: 1472: 85.04
+	Hs
		1057273 SMC1A_HUMAN (2-1203): 1.02e-72: 267: 16.27		PDS5A_HUMAN (2-1350): 0: 1448: 67.21
+	Mm
		93884 SMC1A_MOUSE (2-1203): 1.02e-72: 267: 16.27		E9QPI5_MOUSE (2-1350): 0: 1438: 67.33
+	Mm
		1149127 SMC1A_MOUSE (2-1203): 1.02e-72: 267: 16.27		PDS5A_MOUSE (2-1350): 0: 1418: 67.04
+	Sp
		193880 SMC3_SCHPO (1-1204): 4.03e-86: 307: 38.97		PDS5_SCHPO (12-1154): 0: 938: 21.96
+	Sp
		293288 SMC1_SCHPO (2-1196): 3.88e-73: 268: 15.69		PDS5_SCHPO (12-1154): 0: 938: 21.96
+	Sc
		810772 SMC3_YEAST (1-1209): 1.82e-81: 293: 29.50		PDS5_YEAST (6-1217): 0: 868: 18.83
+	Mm
		1154102 SMC3_MOUSE (1-1209): 3.68e-119: 401: 95.81		NIPBL_MOUSE (1052-1462): 2.9e-10: 67.6: 10.12
+	Hs
		1154087 SMC3_HUMAN (1-1209): 6.66e-119: 400: 95.73		NIPBL_HUMAN (1052-1459): 5.05e-10: 66.8: 11.19
+	Hs
		69118 SMC1A_HUMAN (2-1203): 1.02e-72: 267: 16.27		A9IYQ1_HUMAN (1047-1344): 2.28e-27: 116: 68.90
+	Hs
		1056828 SMC1A_HUMAN (2-1203): 1.02e-72: 267: 16.27		MDC1_HUMAN (1081-1455): 6.7e-11: 69.5: 15.83
+	Hs
		1057289 SMC1A_HUMAN (2-1203): 1.02e-72: 267: 16.27		NIPBL_HUMAN (1052-1459): 5.05e-10: 66.8: 11.19