HitPredict

Interactor 1: RAD21 (O93310)
Double-strand-break repair protein rad21 homolog (SCC1 homolog) [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product)]
Gene: RAD21

Interactor 2: Q8AW91 (Q8AW91)
Structural maintenance of chromosomes protein
Gene: smc3.L

Species: Xenopus laevis

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	10931856
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Rad21_Rec8~SMC_N, Rad21_Rec8_N~SMC_N
Common GO terms	GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 629 Xl			1 1217
+	Xl
		1150103 Q6DCL7_XENLA (1-629): 0: 684: 95.39		Q8AW91_XENLA (1-1217): 5.12e-130: 430: 100.00
+	Xl
		292737 RAD21_XENLA (1-629): 0: 687: 100.00		SMC3_XENLA (1-1217): 3.66e-127: 422: 99.18
+	Hs
		224554 RAD21_HUMAN (1-629): 0: 649: 83.15		SMC3_HUMAN (1-1217): 3.79e-127: 422: 96.71
+	Mm
		1142822 RAD21_MOUSE (1-629): 0: 643: 82.63		SMC3_MOUSE (1-1217): 2.26e-127: 423: 96.80
+	Xl
		292726 RAD21_XENLA (1-629): 0: 687: 100.00		SMC1A_XENLA (2-1211): 3.35e-74: 271: 15.56
+	Mm
		57599 RD21L_MOUSE (1-629): 2.22e-178: 519: 40.64		SMC3_MOUSE (1-1217): 2.26e-127: 423: 96.80
+	Hs
		224434 RAD21_HUMAN (1-629): 0: 649: 83.15		SMC1A_HUMAN (2-1211): 3.37e-79: 286: 15.88
+	Mm
		1142821 RAD21_MOUSE (1-629): 0: 643: 82.63		SMC1A_MOUSE (2-1211): 2.26e-79: 287: 15.88
+	Hs
		224536 RAD21_HUMAN (1-629): 0: 649: 83.15		SMC4_HUMAN (1-1208): 4.78e-77: 281: 17.24
+	Hs
		224250 RAD21_HUMAN (1-629): 0: 649: 83.15		SMC2_HUMAN (1-1217): 5.11e-74: 271: 19.13
+	Hs
		224479 RAD21_HUMAN (1-629): 0: 649: 83.15		SMC1B_HUMAN (2-1217): 7.85e-72: 264: 14.62
+	Mm
		1142818 RAD21_MOUSE (1-629): 0: 643: 82.63		SMC1B_MOUSE (2-1217): 1.02e-67: 252: 14.39
+	Dm
		332181 O96689_DROME (1-628): 1.12e-164: 489: 36.53		Q9VXE9_DROME (1-1217): 5e-105: 361: 52.63
+	Mm
		57598 RD21L_MOUSE (1-629): 2.22e-178: 519: 40.64		SMC1A_MOUSE (2-1211): 2.26e-79: 287: 15.88
+	Mm
		57597 RD21L_MOUSE (1-629): 2.22e-178: 519: 40.64		SMC1B_MOUSE (2-1217): 1.02e-67: 252: 14.39
+	Dm
		332177 O96689_DROME (1-628): 1.12e-164: 489: 36.53		Q9VCD8_DROME (2-1212): 3.09e-68: 253: 14.52
+	Sp
		193873 RAD21_SCHPO (1-623): 1.09e-115: 360: 22.96		SMC3_SCHPO (1-1212): 3.62e-90: 318: 39.03
+	Sc
		810785 REC8_YEAST (23-611): 1.72e-117: 367: 15.08		SMC3_YEAST (1-1217): 4.95e-85: 304: 29.88
+	Sp
		293280 RAD21_SCHPO (1-623): 1.09e-115: 360: 22.96		SMC1_SCHPO (2-1204): 7.59e-71: 261: 15.36
+	Sc
		700809 REC8_YEAST (23-611): 1.72e-117: 367: 15.08		SMC1_YEAST (2-1204): 4.31e-67: 249: 17.45