HitPredict

Interactor 1: MPR1 (O94321)
Multistep phosphorelay regulator 1
Gene: MPR1

Interactor 2: MCS4 (P87323)
Response regulator mcs4 (Mitotic catastrophe suppressor 4)
Gene: MCS4

Species: Schizosaccharomyces pombe 972h-

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.960

Property	Details
Experiments	10940030, 18406331, 20946853, 26771498, 10749922, 17559414, 23695164
Identification Methods	two hybrid, affinity chromatography technology, enzymatic study, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Hpt~Response_reg
Common GO terms	GO:0000160 - phosphorelay signal transduction system GO:0005737 - cytoplasm GO:0010972 - negative regulation of G2/M transition of mitotic cell cycle GO:1900745 - positive regulation of p38MAPK cascade
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 295 Sp			1 522
+	Sp
		145316 MPR1_SCHPO (1-295): 0: 573: 100.00		PRR1_SCHPO (196-492): 6.07e-42: 159: 19.43
+	Sp
		292987 MPR1_SCHPO (1-295): 0: 573: 100.00		MAK1_SCHPO (360-502): 3.79e-32: 133: 30.14
+	Sp
		144037 MPR1_SCHPO (1-295): 0: 573: 100.00		MAK2_SCHPO (352-504): 2e-19: 94.5: 24.36
+	Sp
		251683 MPR1_SCHPO (1-295): 0: 573: 100.00		MAK3_SCHPO (361-504): 1.05e-18: 92.2: 22.45
+	Sc
		990774 YPD1_YEAST (187-246): 1.6e-29: 111: 52.46		SSK1_YEAST (259-522): 7.01e-46: 172: 37.27
+	Sc
		757084 YPD1_YEAST (187-246): 1.6e-29: 111: 52.46		SKN7_YEAST (201-515): 7.99e-42: 160: 19.44
+	Sc
		764838 YPD1_YEAST (187-246): 1.6e-29: 111: 52.46		SLN1_YEAST (215-504): 3.88e-38: 151: 24.04