HitPredict

Interactor 1: ST17B (O94768)
Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2)
Gene: STK17B

Interactor 2: EPHA1 (P21709)
Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH)
Gene: EPHA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~fn3, PK_Tyr_Ser-Thr~Pkinase, Pkinase~SAM_1
Common GO terms	GO:0004672 - protein kinase activity GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0046777 - protein autophosphorylation
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 372 Hs			1 976
+	Hs
		600571 KCC1A_HUMAN (24-293): 1.63e-120: 354: 35.19		EPHA1_HUMAN (1-976): 0: 1103: 100.00
+	Hs
		665151 AKT1_HUMAN (1-349): 6.9e-132: 387: 24.51		EPHA2_HUMAN (24-976): 0: 1056: 49.90
+	Hs
		600539 DAPK1_HUMAN (24-297): 2.69e-78: 263: 48.75		EPHA1_HUMAN (1-976): 0: 1103: 100.00
+	Hs
		1039080 KCC2D_HUMAN (31-370): 9.54e-131: 385: 29.28		EPHAA_HUMAN (3-975): 0: 939: 38.44
+	Hs
		279867 TRIO_HUMAN (26-294): 8.85e-49: 178: 34.94		EPHA7_HUMAN (2-975): 0: 1117: 43.22
+	Hs
		600632 TITIN_HUMAN (34-295): 4.33e-50: 182: 35.12		EPHA1_HUMAN (1-976): 0: 1103: 100.00
+	Hs
		435552 AKT1_HUMAN (1-349): 6.9e-132: 387: 24.51		IGF1R_HUMAN (269-885): 5.75e-137: 446: 21.38
+	Mm
		546263 AKT1_MOUSE (1-349): 2.11e-132: 389: 24.51		INSR_MOUSE (387-882): 4.57e-130: 427: 26.40
+	Hs
		983604 KCC2D_HUMAN (31-370): 9.54e-131: 385: 29.28		FAK1_HUMAN (630-884): 1.18e-63: 236: 45.88
+	Ce
		220204 KCC2D_CAEEL (27-293): 5.69e-119: 362: 34.83		SRC2_CAEEL (630-884): 6.39e-63: 223: 45.35