HitPredict

Interactor 1: MTA2 (O94776)
Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex)
Gene: MTA2

Interactor 2: MECOM (Q03112)
Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein homolog) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein) (Myelodysplasia syndrome-associated protein 1)
Gene: MECOM

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	30462309, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription GO:0045893 - positive regulation of DNA-templated transcription GO:0046872 - metal ion binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 668 Hs			1 1230
+	Hs
		296143 MTA2_HUMAN (1-668): 0: 776: 100.00		PRD16_HUMAN (1-1230): 0: 813: 44.40
+	Hs
		1031953 MTA1_HUMAN (1-668): 0: 704: 56.24		PRD16_HUMAN (1-1230): 0: 813: 44.40
+	Hs
		974549 MTA1_HUMAN (1-668): 0: 704: 56.24		MECOM_HUMAN (1-1230): 0: 666: 90.02
+	Hs
		1223942 RCOR2_HUMAN (134-666): 1.84e-82: 271: 16.25		PRD16_HUMAN (1-1230): 0: 813: 44.40
+	Hs
		1335045 RCOR1_HUMAN (145-597): 1.42e-65: 225: 15.27		PRD16_HUMAN (1-1230): 0: 813: 44.40
+	Hs
		974691 RCOR1_HUMAN (145-597): 1.42e-65: 225: 15.27		MECOM_HUMAN (1-1230): 0: 666: 90.02
+	Hs
		1238812 RCOR3_HUMAN (147-666): 2.93e-89: 288: 14.62		ZN383_HUMAN (770-935): 1.34e-18: 92.4: 17.58