HitPredict - High confidence protein-protein interactions

Interactor 1: MTA2 (O94776)
Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex)
Gene: MTA2

Interactor 2: MTA1 (Q13330)
Metastasis-associated protein MTA1
Gene: MTA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.909

Property	Details
Experiments	12920132, 24981860, 34026424, 35235311, 21670149
Identification Methods	affinity chromatography technology, pull down, cross-linking study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	BAH~BAH, GATA~GATA, Myb_DNA-binding~Myb_DNA-binding
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003682 - chromatin binding GO:0003713 - transcription coactivator activity GO:0003714 - transcription corepressor activity GO:0005634 - nucleus and 10 others more... GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling GO:0016581 - NuRD complex GO:0042659 - regulation of cell fate specification GO:0042826 - histone deacetylase binding GO:0045892 - negative regulation of DNA-templated transcription GO:0045893 - positive regulation of DNA-templated transcription GO:0046872 - metal ion binding GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding GO:2000736 - regulation of stem cell differentiation
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1	668
Hs

1	715

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Last updated: 15 Jul 2024