HitPredict

Interactor 1: MTA2 (O94776)
Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex)
Gene: MTA2

Interactor 2: P66B (Q8WXI9)
Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68)
Gene: GATAD2B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.944

The method score is based on:

Property	Details
Experiments	26186194, 28514442, 11756549, 24981860, 33961781, 26816381
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	GATA~GATA
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000781 - chromosome, telomeric region GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm and 8 others more... GO:0006338 - chromatin remodeling GO:0016581 - NuRD complex GO:0032991 - protein-containing complex GO:0042659 - regulation of cell fate specification GO:0043565 - sequence-specific DNA binding GO:0045892 - negative regulation of DNA-templated transcription GO:0045893 - positive regulation of DNA-templated transcription GO:2000736 - regulation of stem cell differentiation
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1	668
Hs

1	593

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024