HitPredict

Interactor 1: MTA2 (O94776)
Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex)
Gene: MTA2

Interactor 2: NACC2 (Q96BF6)
Nucleus accumbens-associated protein 2 (NAC-2) (BTB/POZ domain-containing protein 14A) (Repressor with BTB domain and BEN domain)
Gene: NACC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	22926524
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0042826 - histone deacetylase binding GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 668 Hs			1 587
+	Hs
		1031922 MTA1_HUMAN (1-668): 0: 704: 56.24		NACC2_HUMAN (1-587): 0: 550: 100.00
+	Hs
		1285480 MTA3_HUMAN (1-570): 0: 660: 64.24		NACC2_HUMAN (1-587): 0: 550: 100.00
+	Mm
		292477 MTA2_MOUSE (1-668): 0: 776: 98.50		ZBT7A_MOUSE (2-485): 2.19e-66: 228: 14.93
+	Hs
		295900 MTA2_HUMAN (1-668): 0: 776: 100.00		ZBT7A_HUMAN (2-482): 7.25e-61: 213: 14.98
+	Hs
		295954 MTA2_HUMAN (1-668): 0: 776: 100.00		BCL6_HUMAN (6-323): 9.06e-44: 168: 21.71
+	Hs
		295994 MTA2_HUMAN (1-668): 0: 776: 100.00		ZBT16_HUMAN (3-307): 1.95e-43: 166: 20.83
+	Hs
		296183 MTA2_HUMAN (1-668): 0: 776: 100.00		ZBTB1_HUMAN (7-118): 1.13e-35: 144: 32.17
+	Mm
		1145309 MTA2_MOUSE (1-668): 0: 776: 98.50		ZBT7B_MOUSE (249-353): 1.56e-14: 78.5: 8.49
+	Hs
		781439 MTA3_HUMAN (1-570): 0: 660: 64.24		BCL6_HUMAN (6-323): 9.06e-44: 168: 21.71
+	Hs
		1031894 MTA1_HUMAN (1-668): 0: 704: 56.24		ZBT46_HUMAN (137-371): 2.86e-12: 71.4: 10.71
+	Mm
		1145234 MTA1_MOUSE (1-668): 0: 696: 56.24		ZBT7B_MOUSE (249-353): 1.56e-14: 78.5: 8.49
+	Mm
		1145265 MTA3_MOUSE (1-573): 0: 643: 64.02		ZBT7B_MOUSE (249-353): 1.56e-14: 78.5: 8.49
+	Hs
		1238812 RCOR3_HUMAN (147-666): 2.93e-89: 288: 14.62		ZN383_HUMAN (115-411): 5.7e-52: 187: 8.55
+	Hs
		166192 RCOR1_HUMAN (145-597): 1.42e-65: 225: 15.27		ZBTB5_HUMAN (7-310): 6.63e-50: 185: 19.38
+	Hs
		1286165 RCOR1_HUMAN (145-597): 1.42e-65: 225: 15.27		ZBTB9_HUMAN (3-249): 1.37e-45: 169: 20.65
+	Hs
		1356500 RCOR1_HUMAN (145-597): 1.42e-65: 225: 15.27		ZBTB1_HUMAN (7-118): 1.13e-35: 144: 32.17
+	Hs
		1198076 RCOR1_HUMAN (145-597): 1.42e-65: 225: 15.27		KAISO_HUMAN (12-145): 7.53e-11: 67: 31.85
+	Hs
		1356484 RCOR1_HUMAN (145-597): 1.42e-65: 225: 15.27		ZBT21_HUMAN (1-143): 8.31e-11: 67: 34.00
+	Hs
		317637 RCOR1_HUMAN (145-597): 1.42e-65: 225: 15.27		ZBT11_HUMAN (10-114): 8.88e-10: 63.9: 35.46
+	Hs
		1229943 MIER1_HUMAN (139-457): 5.07e-61: 214: 17.63		ZBT38_HUMAN (14-141): 1.19e-10: 66.6: 34.82