HitPredict

Interactor 1: UBP1 (O94782)
Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment]
Gene: USP1

Interactor 2: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.888

Property	Details
Experiments	30456385, 30576655, 22195557, 19075014
Identification Methods	enzymatic study, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UCH~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 785 Hs			1 685
+	Hs
		476599 UBP20_HUMAN (32-655): 1.39e-108: 354: 17.83		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476097 UBP33_HUMAN (25-643): 3.73e-102: 338: 16.34		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476644 UBP16_HUMAN (12-633): 5.27e-75: 262: 16.71		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476452 UBP40_HUMAN (388-784): 7.2e-72: 258: 21.14		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476497 UBP35_HUMAN (44-706): 4.89e-71: 253: 14.80		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475957 UBP45_HUMAN (64-633): 6.78e-70: 247: 16.34		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476493 UBP36_HUMAN (418-610): 1.18e-50: 194: 21.54		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476624 UBP15_HUMAN (361-655): 6.89e-46: 179: 16.77		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475566 UBP46_HUMAN (65-298): 1.53e-41: 157: 20.00		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476579 UBP22_HUMAN (25-382): 2.14e-39: 155: 14.36		UBC_HUMAN (1-685): 0: 846: 100.00
+	Dm
		477538 NOT_DROME (424-627): 9.66e-61: 215: 22.12		UBIQP_DROME (1-610): 0: 752: 99.84
+	Mm
		476967 UBP16_MOUSE (11-633): 1.15e-79: 274: 18.01		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		171510 UBP16_HUMAN (12-633): 5.27e-75: 262: 16.71		UBD_HUMAN (155-304): 5.41e-28: 112: 32.05
+	Mm
		476891 UBP40_MOUSE (320-784): 2.65e-68: 247: 16.77		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Mm
		476898 UBP44_MOUSE (380-664): 6.16e-63: 226: 21.97		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		924201 UBP36_HUMAN (418-610): 1.18e-50: 194: 21.54		RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00
+	Mm
		476926 UBP15_MOUSE (361-655): 3.73e-46: 180: 16.46		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Mm
		476741 UBP46_MOUSE (65-298): 1.53e-41: 157: 20.00		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Mm
		477008 UBP12_MOUSE (64-306): 2.31e-41: 157: 20.54		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		474982 UBP46_HUMAN (65-298): 1.53e-41: 157: 20.00		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70